Description and applications

Mouse antibody against Human Integrin alpha V (CD51) (Subclass: IgG1)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression.

Applications:  FACS IHC IP 

Commercially available at EMD Millipore

Publications

Henning et al. 2005. Gene Ther. 12(3):211-24. PMID: 15510176.
Levy et al. 2000. Mol Biol Cell. 11(2):453-66. PMID: 10679006.
Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Keywords

Integrin alpha 5, osteoclasts, cell-cell adhesion, antibody, CD51, melanoma

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