Research
Antibody

Specificity: Human; Applications: FACS IHC IP

Description and applications

Mouse antibody against Human Integrin alpha V ß3 (CD51/61; Osteoclast Functional Antigen) (Subclass: IgG1)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha V associates with integrin beta3 to form the osteoclast functional antigen (vitronectin receptor). Integrin alpha V is found in osteoclasts, placenta, melanoma cell lines and some epithelial cell lines. Expression of integrin alpha V increases with melanoma progression. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.

Applications:  FACS IHC IP 

Commercially available at Research and diagnostic systems, Biolegend and Miltenyi Biotech Gmbh

Publications

Martino et al. 2009. Biomaterials. 30(6):1089-97. PMID: 19027948.
Zhou et al. 2006. J Exp Med. 203(4):1067-80. PMID: 16606672.
Marshall et al. 1995. J Cell Sci. 108 ( Pt 3):1227-38. PMID: 7542669.
Horton et al. 1985. Cancer Res. 45(11 Pt 2):5663-9. PMID: 4053038.

Keywords

Integrin alpha v beta 3, osteoclasts, cell-cell adhesion, antibody, CD51/61, melanoma, Integrin alpha V ß3

Prof Michael Horton

Previously at Barts hospital

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