Research
Antibody

Specificity: Human; Applications: FACS IHC IF IP

Description and applications

Mouse antibody against human Integrin ß1 (CD29) (Subclass: IgG1)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Loss of integrin beta 1 is associated with the development of some epithelial tumours.

Applications:  FACS IHC IF IP 

Commercially available at Research and Diagnostic systems

Publications

Marshall et al. 1998. Br J Cancer. 77(4):522-9. PMID: 9484806.

Keywords

Integrin beta 1, melanoma, cell-cell adhesion, antibody, CD29, cancer

Prof Michael Horton

Previously at Barts hospital

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