Research
Antibody

Specificity: Human; Applications: FACS IHC IF IP WB

Description and applications

1-  Mouse antibody against Protein tyrosine phosphatase, receptor type, C (PTPRC, CD45R) (Subclass: IgGM)

PTPRC (CD45) is a transmembrane tyrosine phosphatase that is present on all leukocytes. PTPRC regulates the threshold of T cell antigen receptor (TCR) signaling through dephosphorylation of protein tyrosine kinases (e.g. Lck and Fyn). CD45R and CD45RO are two of multiple PTPRC isoforms generated by alternative splicing. CD45R is found on B lymphocyte and T lymphocyte subsets. CD45RO is present on 50% of T cells, most granulocytes and monocytes and most mature T cell tumours. 351C5 may be used in the typing of leukaemias and lymphomas and in studies of functional subsets of B and T cells.

Applications:  FACS IHC IF IP WB

Commercially available at Adipogen. In collaboration with John Habeshaw

Publications

Leitenberg et al. 1996. J Exp Med. 183(1):249-59. PMID: 8551228.

Trowbridge et al. 1994. Annu Rev Immunol. 12:85-116. PMID: 8011300.

Murray et al. 1985. Clin Exp Immunol. 59(2):315-26. PMID: 3872187.

Keywords

Antibody, Protein tyrosine phosphatase receptor type, C, PTPRC, CD45R, Lymphocyte, leukemia, lymphoma

Prof Irene Leigh

Previously at Blizard Institute

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