Research
Antibody

Specificity: Human; Applications: FACS IHC IF IP

Description and applications

Mouse antibody against human ICAM1 (CD54) (Subclass: IgG1)

ICAMs are members of the immunoglobulin superfamily that is characterised by the presence of immunoglobulin-like domains. ICAM-1 is expressed in haemopoietic cells and vascular endothelium. Cytokine activation causes ICAM-1 expression in other cell types such as fibroblasts and keratinocytes. ICAM-1 is involved in leukocyte recruitment and inflammation. ICAM-1 binds LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). P1W16 may be useful for prognosis of malignant melanoma.

Applications:  FACS IHC IP IF

Commercially available at Novus Biologicals

Keywords

ICAM1, haematopoietic cells, endothelium, inflammation, leukocyte recruitment, melanoma

Prof John Marshall

Barts Cancer Institute

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