Research
Antibody

Specificity: Human; Applications: FACS IF

Description and applications

1-  Rat antibody against Human Integrin alpha v/beta 6 (Subclass: IgG2a)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.

Applications:  FACS IF 

Publications

Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.

Commercially available at Abcore

Keywords

Integrin alpha v beta 6, melanoma, cancer, antibody, Integrin alpha V ß6, metastasis

Prof John Marshall

Barts Cancer Institute

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