Research
Antibody

Specificity: Human and Rat; Applications: FACS IHC IP

Description and applications

Mouse antibody against Human and Rat Integrin ß3 (CD61) (Subclass: IgG1)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin b3 is expressed in osteoclasts, megacaryocytes and platelets. The F11 epitope is different to the MHF4 epitope.

Applications:  FACS IHC IP 

Publications

de Nigris et al. 2007. Oncogene. 26(3):382-94. PMID: 16878156.
Thompson et al. 2000. J Immunol. 165(1):426-34. PMID: 10861081.

Shankar et al. 1993. J Cell Sci. 105 ( Pt 1):61-8. PMID: 7689577.
Helfrich et al. 1992. J Bone Miner Res. 7(3):345-51. PMID: 1585837.
Helfrich et al. 1992. J Bone Miner Res. 7(3):335-43. PMID: 1585836.

Keywords

Integrin beta 3, cell-cell adhesion, antibody, CD61, melanoma, cancer, osteoclasts

Prof Michael Horton

Previously at Barts hospital

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