Research
Antibody

Specificity: Human and Rat; Applications: FACS IHC IP IF

Description and applications

Mouse antibody against Human and Rat Integrin ß3 chain (CD61) (Subclass: IgG2a)

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin b3 is expressed in osteoclasts, megacaryocytes and platelets. MHF4 may be used to identify osteoclasts in tissue sections and bone cell suspensions. The MHF4 epitope is different to the F11 epitope.

Applications:  FACS IHC IP IF

Commercially available at Novus Biologicals and Santa Cruz Biotechnology

Publications

Ballana et al. 2011. J Immunol. 186(1):464-70. PMID: 21098231.
Helfrich et al. 1992. J Bone Miner Res. 7(3):345-51. PMID: 1585837.

Keywords

Integrin beta 3, osteoclasts, cell-cell adhesion, antibody, CD61, melanoma, cancer

Prof Michael Horton

Previously at Barts hospital

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