Research
Antibody

Specificity: Amphibian and Mammalian; Applications: IHC IF WB

Description and applications

1-  Mouse antibody against Amphibian and Mammalian Keratin 7 (Subclass: IgG1)

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratins 7 and 8 are two closely related type II keratins characteristic of simple epithelia. Keratin 7 is less widespread than keratin 8 and is expressed in sebaceous and sweat glands and some cells of the inner hair root sheath. Keratin 7 is often co-expressed with keratin 19. LP1K has some weak reactivity with keratin 8 and other type II keratins.

Applications:  IHC IF WB

Commercially available at Abcore

Publications

Zhang et al. 2013. Cell Death Dis. 4:e502. PMID: 23429288.

Zhang et al. 2012. PLoS One. 7(6):e38487. PMID: 22679510.

Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.
 
Lane EB et al. 1985. Ann. NY Acad. Sci. 455:241-58.PMID: 2417515.

Keywords

Antibody, Keratin 7, keratinocyte, sebaceous glands, sweat glands

Prof Irene Leigh

Previously at Blizard Institute

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