Animal model

Rodent model of fixed-pressure haemorrhagic shock

Description and applications

Rodent model of fixed-pressure haemorrhagic shock (90mins).

Preclinical modelling of massive bleeding and hypovolemic shock to conduct translational and discovery research of coagulopathy and measure the impact of systemic inflammatory response to injury and cellular hypoxia in the context of organ dysfunction.


Frith D et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations???. J Thromb Haemost. 2010 Sep;8(9):1919-25.

Barts Centre for Trauma Sciences


Haemorrhage, Shock, Coagulopathy

Prof Karim Brohi and Dr Simon Eaglestone

Blizard Institute

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