Part of the apoptosis-inducing viral E1A gene is expressed from a CMV promoter in the adenoviral backbone (the small E1A12S domain). Used as gene transfer tool and control vector.
Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR, Halldén G. (2012) Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region. PLoS One. 2012;7(10):e46617. doi: 10.1371/journal.pone.0046617. Epub 2012 Oct 3.
Barts Cancer Institute
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