Description and applications
An engineered adenovirus deleted in the E1ACR2 region and the anti-apoptotic E1B19K gene (AdΔΔ). Selectively replicates and lyses cancer cells with deregulated cell cycle control.
- Öberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G. Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant (AdΔΔ) in prostate and pancreatic cancers. Clin Cancer Res, 2010. PMID: 20068104
- Leitner S, Sweeney K, Öberg D, Miranda E, Lemoine NR, Halldén G. Oncolytic adenoviral mutants with E1B19K-gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumour efficacy in vivo. Clin Cancer Res, 2009. PMID: 19223497
- Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR, Halldén G. (2011) The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA damaging drugs in pancreatic cancer models. Gene Therapy Dec;18(12):1157-65
adenovirus, replication-selective, cancer cell lysis
Dr Gunnel Halldén
Barts Cancer Institute