Description and applications
An engineered adenovirus deleted in the anti-apoptotic E1B19K gene (AdΔ19K). Preferential replication in cancer cells with deregulated apoptosis and enhanced drug-induced cell killing.
- Öberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR, Halldén G. Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant (AdΔΔ) in prostate and pancreatic cancers. Clin Cancer Res, 2010. PMID: 20068104
- Leitner S, Sweeney K, Öberg D, Miranda E, Lemoine NR, Halldén G. Oncolytic adenoviral mutants with E1B19K-gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumour efficacy in vivo. Clin Cancer Res, 2009. PMID: 19223497
adenovirus, replication-selective, apoptosis
Dr Gunnel Halldén
Barts Cancer Institute