Pragmatic Clinical Trials Unit

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Introduction to Trials within Cohorts ( TwiCs) - 2020

Who this course is for

Anyone involved in the design, conduct, analysis or reporting of pragmatic trials in the academic or NHS sector. The course will be of interest to all triallists, including principal investigators, trial managers, early career researchers and PhD students

Course content

This practical one-day course will provide participants with an understanding of the key features of the TwiCs approach to pragmatic trial design. 

The day will include information and guidance on how to plan studies using this approach, how to analyse TwiCs trials, different ways to approach informed consent, how to obtain HRA and MHRA approvals, and how to report TwiCs trials.

Course participants will be provided with a wide range of examples of UK and international studies using the TwiCs approach (e.g. mental health, cancer, musculoskeletal diseases).

We will discuss the strengths and weaknesses of the TwiCs approach compared to the standard approach to pragmatic trial design and other innovative approaches to trial design which also leverage existing databases for trials (e.g. randomised registry trials, electronic health record/ point-of-care trials, administrative trials and platform trials.)


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