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OW3 Research

Leica SP8 Confocal

An upright laser scanning confocal microscope equipped for high temporal and spatial resolution imaging of fixed cells or tissue sections, as well as live tissue and in vivo intravital techniques.



For a full system specification, visit the CMR Advanced Bio-imaging Facility website. In brief, the system is configured with a super-continuum white light laser for user-specified selection of any laser line (and up to eight simultaneously) between 470-670 nm. The microscope has four objective lens options (10x/0.3 W Apo, 20x/1.0 W Apo, 63x/0.9 W Apo, 63x/1.4 oil Pl Apo), and two high-sensitivity Hybrid detectors, in addition to two PMT detectors for fast multi-channel capture.



With this confocal laser scanning technology, high-quality optical Z-sections can be acquired to generate high-resolution multi-channel 3/4D images of fixed or live samples. 

Unique to Leica technology, this system is equipped with state-of-the-art, fully tunable excitation and detection technology, allowing users to precisely set the optimal parameters for any fluorophore within the 470-670 nm excitation range, ideal for challenging and unusual fluorophores combinations.

The large stage area, water dipping lenses and ultra-fast resonant scanner, make this system well-suited to the challenges of live tissue and intravital imaging experiments. The long working distance collection of objective lenses (up to 3.6 mm) can enable deep imaging within cleared tissues and the large stage area can accommodate large or unusal sample types that don't have to conform to the standard slide or imaging chamber mount. 


Price per hour : £25

Price O/N : n/a

Contact details

Facility : CMR Advanced Bio-imaging Facility

Campus : Charterhouse Square

Address : Centre for Microvascular Research, William Harvey Research Institute, Charterhouse Square, EC1M 6BQ

Manager : Dr Mathieu-Benoit Voisin

Contact : 020 7882 3910

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