Dr Jamie GriffinLecturer in Applied ProbabilityEmail: j.griffin@qmul.ac.ukTelephone: +44 (0)20 7882 3648Room Number: Mathematical Sciences Building, Room: B26Office Hours: Tuesday 11.30 - 13.30 ProfilePublicationsProfileJamie Griffin is a Lecturer in Applied Probability. His main research area is modelling malaria transmission and control. This research has involved synthesising multiple types of data to be able to make predictions of the impact of interventions in reducing malaria transmission. He has advised policymakers at the WHO on a number of questions covering vaccines and other interventions against malaria. He has also worked on more general problems of statistical inference for infectious diseases. Before joining Queen Mary, he held an MRC Methodology fellowship at Imperial College. He continues to collaborate with the malaria modelling group there. He also collaborates with a number of staff in the Malaria Centre at the London School of Hygiene and Tropical Medicine. ResearchPublications Walker PGT, Cairns M, Slater H et al. (2020). Modelling the incremental benefit of introducing malaria screening strategies to antenatal care in Africa Nature Communications nameOfConference. 10.1038/s41467-020-17528-3 https://qmro.qmul.ac.uk/xmlui/handle/123456789/67338 Verity R, Okell LC, Dorigatti I et al. (2020). Estimates of the severity of coronavirus disease 2019: a model-based analysis The Lancet Infectious Diseases nameOfConference. 10.1016/S1473-3099(20)30243-7 https://qmro.qmul.ac.uk/xmlui/handle/123456789/64108 Bretscher MT, Dahal P, Griffin J et al. (2020). The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: A meta-analysis of individual patient data BMC Medicine nameOfConference. 10.1186/s12916-020-1494-3 https://qmro.qmul.ac.uk/xmlui/handle/123456789/63439 Sherrard-Smith E, Skarp JE, Beale AD et al. (2019). Mosquito feeding behavior and how it influences residual malaria transmission across Africa Proceedings of the National Academy of Sciences of the United States of America nameOfConference. 10.1073/pnas.1820646116 https://qmro.qmul.ac.uk/xmlui/handle/123456789/59241 Sherrard-Smith E, Griffin JT, Winskill P et al. (2018). Systematic review of indoor residual spray efficacy and effectiveness against Plasmodium falciparum in Africa Nature Communications nameOfConference. 10.1038/s41467-018-07357-w https://qmro.qmul.ac.uk/xmlui/handle/123456789/54694 Hogan AB, Winskill P, Verity R et al. (2018). Modelling population-level impact to inform target product profiles for childhood malaria vaccines BMC Medicine nameOfConference. 10.1186/s12916-018-1095-6 https://qmro.qmul.ac.uk/xmlui/handle/123456789/43125 Watson OJ, Routledge I, Griffin JT et al. (2018). Predictive Malaria Epidemiology, Models of Malaria Control Interventions and Elimination journal nameOfConference. 10.1007/978-1-4614-8757-9_146-1 qmroHref Routledge I, Watson OJ, Griffin JT et al. (2018). Predictive Malaria Epidemiology, Models of Malaria Transmission and Elimination journal nameOfConference. 10.1007/978-1-4614-8757-9_79-1 qmroHref Winskill P, Slater HC, Griffin JT et al. (2017). The US President's Malaria Initiative, Plasmodium falciparum transmission and mortality: A modelling study PLoS Medicine nameOfConference. 10.1371/journal.pmed.1002448 https://qmro.qmul.ac.uk/xmlui/handle/123456789/31428 Bretscher MT, Griffin JT, Ghani AC et al. (2017). Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium falciparum transmission by case management or by mass treatment Malaria Journal nameOfConference. 10.1186/s12936-017-1988-4 https://qmro.qmul.ac.uk/xmlui/handle/123456789/25582 Okell LC, Griffin JT, Roper C (2017). Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa Scientific Reports nameOfConference. 10.1038/s41598-017-06708-9 https://qmro.qmul.ac.uk/xmlui/handle/123456789/25580 Patouillard E, Griffin J, Bhatt S et al. (2017). Global investment targets for malaria control and elimination between 2016 and 2030 BMJ Global Health nameOfConference. 10.1136/bmjgh-2016-000176 https://qmro.qmul.ac.uk/xmlui/handle/123456789/24518 Winskill P, Walker PGT, Griffin JT et al. (2017). Modelling the cost-effectiveness of introducing the RTS,S malaria vaccine relative to scaling up other malaria interventions in sub-Saharan Africa BMJ Global Health nameOfConference. 10.1136/bmjgh-2016-000090 https://qmro.qmul.ac.uk/xmlui/handle/123456789/19553 Churcher TS, Sinden RE, Edwards NJ et al. (2017). Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts PLOS Pathogens nameOfConference. 10.1371/journal.ppat.1006108 https://qmro.qmul.ac.uk/xmlui/handle/123456789/24654 Churcher TS, Lissenden N, Griffin JT et al. (2016). The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa. eLife nameOfConference. 10.7554/eLife.16090 https://qmro.qmul.ac.uk/xmlui/handle/123456789/67339 Griffin JT (2016). Is a reproduction number of one a threshold for Plasmodium falciparum malaria elimination? Malaria Journal nameOfConference. 10.1186/s12936-016-1437-9 https://qmro.qmul.ac.uk/xmlui/handle/123456789/22539 Walker PG, Griffin JT, Ferguson NM et al. (2016). Estimating the most efficient allocation of interventions to achieve reductions in Plasmodium falciparum malaria burden and transmission in Africa: a modelling study. The Lancet Global Health nameOfConference. 10.1016/S2214-109X(16)30073-0 https://qmro.qmul.ac.uk/xmlui/handle/123456789/67340 Marshall JM, Touré M, Ouédraogo AL et al. (2016). Key traveller groups of relevance to spatial malaria transmission: a survey of movement patterns in four sub-Saharan African countries. Malaria Journal nameOfConference. 10.1186/s12936-016-1252-3 qmroHref Penny MA, Verity R, Bever CA et al. (2016). Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: A systematic comparison of predictions from four mathematical models The Lancet nameOfConference. 10.1016/S0140-6736(15)00725-4 qmroHref Griffin JT, Bhatt S, Sinka ME et al. (2016). Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study. Lancet Infectious Diseases nameOfConference. 10.1016/S1473-3099(15)00423-5 qmroHref Slater HC, Griffin JT, Ghani AC et al. (2016). Assessing the potential impact of artemisinin and partner drug resistance in sub-Saharan Africa Malaria Journal nameOfConference. 10.1186/s12936-015-1075-7 qmroHref White MT, Verity R, Griffin JT et al. (2015). Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: Secondary analysis of data from a phase 3 randomised controlled trial The Lancet Infectious Diseases nameOfConference. 10.1016/S1473-3099(15)00239-X qmroHref Van Den Hoogen LL, Griffin JT, Cook J et al. (2015). Serology describes a profile of declining malaria transmission in Farafenni, the Gambia Malaria Journal nameOfConference. 10.1186/s12936-015-0939-1 qmroHref Bhatt S, Weiss DJ, Cameron E et al. (2015). The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015 Nature nameOfConference. 10.1038/nature15535 qmroHref Cameron E, Battle KE, Bhatt S et al. (2015). Defining the relationship between infection prevalence and clinical incidence of Plasmodium falciparum malaria Nature Communications nameOfConference. 10.1038/ncomms9170 qmroHref Cairns ME, Walker PGT, Okell LC et al. (2015). Seasonality in malaria transmission: Implications for case-management with long-acting artemisinin combination therapy in sub-Saharan Africa Malaria Journal nameOfConference. 10.1186/s12936-015-0839-4 qmroHref Walker PGT, White MT, Griffin JT et al. (2015). Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: A modelling analysis The Lancet Infectious Diseases nameOfConference. 10.1016/S1473-3099(15)70124-6 qmroHref Griffin JT, Hollingsworth TD, Reyburn H et al. (2015). Gradual acquisition of immunity to severe malaria with increasing exposure Proceedings. Biological sciences / The Royal Society nameOfConference. 10.1098/rspb.2014.2657 qmroHref Griffin JT (2015). The interaction between seasonality and pulsed interventions against malaria in their effects on the reproduction number. PLoS Comput Biol nameOfConference. 10.1371/journal.pcbi.1004057 https://qmro.qmul.ac.uk/xmlui/handle/123456789/31977 White MT, Griffin JT, Akpogheneta O et al. (2014). Dynamics of the antibody response to Plasmodium falciparum infection in African children Journal of Infectious Diseases nameOfConference. 10.1093/infdis/jiu219 qmroHref Bretscher MT, Griffin JT, Hugo P et al. (2014). A comparison of the duration of post-treatment protection of artemether-lumefantrine, dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated malaria Malaria Journal nameOfConference. 10.1186/1475-2875-13-s1-p19 qmroHref Pinsent A, Read JM, Griffin JT et al. (2014). Risk factors for UK Plasmodium falciparum cases Malaria Journal nameOfConference. 10.1186/1475-2875-13-298 qmroHref White MT, Bejon P, Olotu A et al. (2014). A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine BMC Medicine nameOfConference. 10.1186/s12916-014-0117-2 qmroHref Griffin JT, Ferguson NM, Ghani AC (2014). Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa Nature Communications nameOfConference. 10.1038/ncomms4136 qmroHref Okell LC, Cairns M, Griffin JT et al. (2014). Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis Nature Communications nameOfConference. 10.1038/ncomms6606 qmroHref White MT, Griffin JT, Ghani AC (2013). The design and statistical power of treatment re-infection studies of the association between pre-erythrocytic immunity and infection with Plasmodium falciparum Malaria Journal nameOfConference. 10.1186/1475-2875-12-278 qmroHref White MT, Bejon P, Olotu A et al. (2013). The Relationship between RTS,S Vaccine-Induced Antibodies, CD4+ T Cell Responses and Protection against Plasmodium falciparum Infection PLoS ONE nameOfConference. 10.1371/journal.pone.0061395 qmroHref Walker PGT, Griffin JT, Cairns M et al. (2013). A model of parity-dependent immunity to placental malaria Nature Communications nameOfConference. 10.1038/ncomms2605 qmroHref Bousema T, Stevenson J, Baidjoe A et al. (2013). The impact of hotspot-targeted interventions on malaria transmission: Study protocol for a cluster-randomized controlled trial Trials nameOfConference. 10.1186/1745-6215-14-36 qmroHref Okell LC, Bousema T, Griffin JT et al. (2012). Factors determining the occurrence of submicroscopic malaria infections and their relevance for control Nature Communications nameOfConference. 10.1038/ncomms2241 qmroHref Bousema T, Griffin JT, Sauerwein RW et al. (2012). Hitting hotspots: Spatial targeting of malaria for control and elimination PLoS Medicine nameOfConference. 10.1371/journal.pmed.1001165 qmroHref Opatowski L, Fraser C, Griffin J et al. (2011). Transmission characteristics of the 2009 h1n1 influenza pandemic: Comparison of 8 southern hemisphere countries PLoS Pathogens nameOfConference. 10.1371/journal.ppat.1002225 qmroHref White MT, Griffin JT, Churcher TS et al. (2011). Modelling the impact of vector control interventions on Anopheles gambiae population dynamics Parasites and Vectors nameOfConference. 10.1186/1756-3305-4-153 qmroHref Okell LC, Griffin JT, Kleinschmidt I et al. (2011). The potential contribution of mass treatment to the control of plasmodium falciparum malaria PLoS ONE nameOfConference. 10.1371/journal.pone.0020179 qmroHref Griffin JT, Garske T, Ghani AC et al. (2011). Joint estimation of the basic reproduction number and generation time parameters for infectious disease outbreaks Biostatistics nameOfConference. 10.1093/biostatistics/kxq058 qmroHref White MT, Griffin JT, Riley EM et al. (2011). Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines Proceedings of the Royal Society B: Biological Sciences nameOfConference. 10.1098/rspb.2010.1697 qmroHref Griffin JT, Cairns M, Ghani AC et al. (2010). Protective efficacy of intermittent preventive treatment of malaria in infants (IPTi) using sulfadoxine- pyrimethamine and parasite resistance PLoS ONE nameOfConference. 10.1371/journal.pone.0012618 qmroHref Griffin JT, Hollingsworth TD, Okell LC et al. (2010). Reducing Plasmodium falciparum malaria transmission in Africa: A model-based evaluation of intervention strategies PLoS Medicine nameOfConference. 10.1371/journal.pmed.1000324 qmroHref Carneiro I, Roca-Feltrer A, Griffin JT et al. (2010). Age-patterns of malaria vary with severity, transmission intensity and seasonality in sub-Saharan Africa: A systematic review and pooled analysis PLoS ONE nameOfConference. 10.1371/journal.pone.0008988 qmroHref White MT, Griffin JT, Drakeley CJ et al. (2010). Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials. Malaria journal nameOfConference. 10.1186/1475-2875-9-82 qmroHref Bousema T, Okell L, Shekalaghe S et al. (2010). Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs. Malaria journal nameOfConference. 10.1186/1475-2875-9-136 qmroHref Ghani A, Baguelin M, Griffin J et al. (2009). The Early Transmission Dynamics of H1N1pdm Influenza in the United Kingdom. PLoS Curr nameOfConference. 10.1371/currents.RRN1130 qmroHref Stewart L, Gosling R, Griffin J et al. (2009). Rapid assessment of malaria transmission using age-specific sero-conversion rates PLoS ONE nameOfConference. 10.1371/journal.pone.0006083 qmroHref Fraser C, Donnelly CA, Cauchemez S et al. (2009). Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings Science nameOfConference. 10.1126/science.1176062 qmroHref Baggaley RF, Griffin JT, Chapman R et al. (2009). Estimating the public health impact of the effect of herpes simplex virus suppressive therapy on plasma HIV-1 viral load AIDS nameOfConference. 10.1097/QAD.0b013e32832aadf2 qmroHref Ghani AC, Sutherland CJ, Riley EM et al. (2009). Loss of population levels of immunity to malaria as a result of exposure-reducing interventions: Consequences for interpretation of disease trends PLoS ONE nameOfConference. 10.1371/journal.pone.0004383 qmroHref Corran PH, Cook J, Lynch C et al. (2008). Dried blood spots as a source of anti-malarial antibodies for epidemiological studies Malaria Journal nameOfConference. 10.1186/1475-2875-7-195 qmroHref Gras L, Kesselring AM, Griffin JT et al. (2007). CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greater Journal of Acquired Immune Deficiency Syndromes nameOfConference. 10.1097/QAI.0b013e31804d685b qmroHref Griffin JT, Fraser C, Gras L et al. (2006). The effect on treatment comparisons of different measurement frequencies in human immunodeficiency virus observational databases American Journal of Epidemiology nameOfConference. 10.1093/aje/kwj083 qmroHref Fidler S, Fraser C, Fox J et al. (2006). Comparative potency of three antiretroviral therapy regimes in primary HIV infection AIDS nameOfConference. 10.1097/01.aids.0000200530.71737.75 qmroHref Ghani AC, Donnelly CA, Cox DR et al. (2005). Methods for estimating the case fatality ratio for a novel, emerging infectious disease American Journal of Epidemiology nameOfConference. 10.1093/aje/kwi230 qmroHref Griffin J (2005). Handbook of Statistics, Volume 23, Advances in Survival Analysis Journal of the Royal Statistical Society Series A (Statistics in Society) nameOfConference. 10.1111/j.1467-985x.2005.00368_2.x qmroHref