2 November 2016
Time: 3:00 - 4:00pm
Venue: PP1 Lecture Theatre, People's Palace, Mile End
Professor Sarah Cartmell, from the University of Manchester, will be giving an Institute of Bioengineering seminar entitled: "Advances in orthopaedic tissue engineering: bioreactor use, electrical stimulation and CT imaging development".
The growing of new bone, cartilage, tendon and ligament tissue in vitro requires a variety of factors that need to be controlled and optimised. These factors (which include the cell type, scaffold type, growth factors / drugs and stimuli such as mechanical and electrical) require the use of a chamber to house the developing tissue and control the applied stimuli. The design and optimal use of several different types of these bioreactors will be discussed, in particular to address the nutrient flow / availability characteristics in direct perfusion bioreactors. The use of a novel electrical bioreactor will also be discussed in addition to the use of a TA Instruments biodynamic instrument to apply mechanical stimuli to a developing tendon construct. The use of computed tomography for imaging and quantifying the developing constructs will also be presented.