2 February 2016
Time: 1:00 - 2:00pm
Venue: Room 2.17, Arts Two, Mile End
The first lecture in the new LSI seminar series will be given by Dr Jesmond Dalli, senior lecturer in metabolipidomics at the William Harvey Research Institute. The talk is on “Profiling of bioactive lipid mediators to nurture inter-disciplinary research”.
Inflammation is a coordinated host response that when self-limited is protective. Many cell types upon activation produce mediators that regulate the physiological function of inflammation.
The initiation of the inflammatory response is orchestrated by arachidonic acid derived mediators that include the leukotrienes, prostaglandins and thromboxane. The termination inflammation, termed "resolution phase" is also appreciated to be an active response coordinated by a novel genus of lipid mediators termed as specialised pro-resolving mediators. These include the arachidonate-derived lipoxins, and the omega-3-derived resolvins, maresins and protectins. Failure to engage these protective pathways is implicated in the development of many inflammatory diseases including infections, cardiovascular disease and neurological disease.
The seminar will introduce the biology of these novel mediators as well as the technology provided by the recently established QMUL Lipid Mediator Unit to simultaneously measure the levels of these bioactive mediators in cell media and biological tissues. This provides a unique opportunity to identify novel molecular pathways, biomarkers and tools to define cell phenotype, as well as the inflammation-resolution status of tissues of interest.
This will be the first of a series of LSI seminars, with details of future events to follow. A sandwich lunch will be provided. For catering purposes please register your attendance.