5 December 2018
Time: 3:00 - 4:00pm
Speaker: Dr Ciro Chiappini
Venue: PP1 People's Palace, Mile End Campus, Queen Mary University of London
Engineering the cell-material interface to direct cell fate carries transformative potential for regenerative medicine, precision medicine and fundamental cell and molecular biology. Vertical arrays of nanowires and nanoneedles are rapidly emerging as promising biointerfaces capable of manipulating cells. Thanks to their high aspect ratio, nanoneedles interact simultaneously with multiple organelles within the cell, enabling gene delivery, intracellular sensing, and direct stimulation of signalling pathways at multiple levels of the mechanosensory machinery. Leveraging these interactions enables gene therapy, epigenetic remodelling and intracellular sensing, yielding dynamic manipulation of cells and their environment with broad impact both in vitro and in vivo.