Department: Barts Cancer InstituteSalary: £37,348 per annum (Grade 4)Reference: QMUL32630Location: Charterhouse SquareDate posted: 12 May 2023Closing date: 16 June 2023
Further details and apply
About the Role
Applications are sought for a Postdoctoral Research Assistant (PDRA) to undertake research under the supervision of Dr Roberto Bellelli for a three years MRC-funded research project to study the role of DNA Polymerase Epsilon in genome and epigenome stability. The post will be based at the Barts Cancer Institute (BCI), Queen Mary University of London (QMUL), with potential access to Francis Crick Institute or Great Ormond Street Hospital for some experimental work.
About You
Essential requirements include having a PhD in a relevant biological subject (or having submitted a thesis for PhD and expecting to have the viva soon), and an undergraduate degree in a biological subject. Significant laboratory experience in genome or epigenome integrity and basic cell & molecular biology is essential. Additional experience in biochemistry (protein expression/purification) or genome sequencing approaches (CUT&TAG, ChIP-Seq, mapping of replication origins) would be an advantage. Good scientific communication, working within a scientific team and maintaining good laboratory records are also essential.
About the School/Department/Institute/Project
The project is based on our previous work on DNA Polymerase Epsilon (Bellelli et al., Mol Cell. 2018 May; Bellelli et al., Mol Cell. 2018 Oct) and aims to reveal the mechanisms by which Pol Epsilon coordinates DNA synthesis and nucleosome assembly at the replication fork by using a combination of biochemistry and genome-sequencing approaches. The candidate will join a vibrant multidisciplinary, multi-institutional environment with a strong critical mass in genome stability and cancer biology.
The BCI is a Cancer Research UK Centre of Excellence and one of six institutes within the Faculty of Medicine and Dentistry (FMD) at QMUL. BCI is internationally renowned in many areas of cancer research and it combines ground-breaking basic research with the expertise of clinicians and clinician scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care. BCI is also a partner in the CRUK City of London Major Centre (together with UCL, Kings and the Francis Crick Institute) and is committed in supporting and developing future cancer researchers through its extensive postgraduate training.
Benefits
We offer competitive salaries, access to a generous pension scheme, 30 days leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work-life balance and family-friendly, inclusive employment policies, flexible working arrangements, and campus facilities including an on-site nursery at the Mile End campus.
The post is based at the Charterhouse Square Campus in London. It is full-time (35 hours per week), fixed term appointment for 2 years. The expected start date of the post is 1st June 2023, but open to negotiation. The starting salary for an entry-level candidate will be Grade 4, Spine point 27 (£37,348) per annum (pro-rata), inclusive of London Allowance.
Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointment processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability.
Informal enquiries should be addressed to Dr. Roberto Bellelli at r.bellelli@qmul.ac.uk
The closing date for applications is 16 June 2023.
Interviews are expected to be held shortly thereafter.
Valuing Diversity & Committed to Equality