Department: Barts Cancer InstituteSalary: £37,348 - £43,592 (Grade 4)Reference: QMUL32860Location: Charterhouse SquareDate posted: 30 May 2023Closing date: 27 June 2023
Further details and apply
About the Project
Oncogene-induced tumour suppression is an important barrier to tumourigenesis driven by oncogene activation. Bypass of tumour suppression is observed in all cancers and understanding the underlying molecular mechanisms will allow for development of novel therapies that can restore tumour suppression in established cancers. Activation of the MYC oncogene leads to activation of the p53 pathway and loss of p53 therefore cooperates with MYC in tumourigenesis. However, the molecular mechanisms underlying MYC-induced p53 activation remain obscure. Through siRNA screening, we have identified an unexpected role for lipid metabolism in this process. The postholder will use molecular biological, biochemical and lipidomic and proteomic techniques to explore how MYC regulates lipid metabolism and how this leads to p53 activation. In addition, they will use genetic and pharmacological tools to assess whether perturbation of lipid metabolism can elicit tumour suppression in mouse models of MYC-induced lymphomagenesis.
About You
The post requires a dedicated, motivated and passionate postdoctoral research assistant who will lead this study. Applicants must have a PhD in a relevant subject and provide three good references. The study requires substantial skills in cell and molecular biology and will require in vivo testing of newly created cell-models. First author publications will provide evidence that you have experience in completing studies through to the final manuscript.
About the School/Department/Institute
The Barts Cancer Institute (BCI) is a Cancer Research UK Centre of Excellence whose work aims to transform the lives of those with and at risk of cancer through innovative research in the laboratory, in patients and in populations. BCI is internationally renowned in areas of cancer research and it combines ground-breaking basic research with the expertise of clinicians and clinician scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care.
About Queen Mary
At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable. Throughout our history, we’ve fostered social justice and improved lives through academic excellence. We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form.
Benefits
We offer competitive salaries, access to a generous pension scheme, 30 days’ leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance employment policies, flexible working arrangements, and campus facilities including on-site nursery at the Mile End campus.
The post is based at the Charterhouse Square Campus in London. It is full time (35 hours per week), fixed term appointment for 3 years, with an expected start date of 3rd July 2023. The starting salary will be Grade 4, in the range of £37,348 - £43,592 per annum (pro-rata), inclusive of London Allowance.
Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to candidates wishing to work flexibly.
Informal enquiries should be addressed to Andy Finch at a.finch@qmul.ac.uk
The closing date for applications is 27 June 2023.
Interviews are expected to be held shortly thereafter.
Valuing Diversity & Committed to Equality