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Institute of Population Health Sciences (IPHS)

Research

ACROBAT- The effect of early cryoprecipitate transfusion versus standard care in women who develop severe postpartum haemorrhage: A pilot cluster randomised trial.

COGS- Core Outcome Sets in Gynaecological Conditions

EMMY- Effectiveness and acceptability of myo-inositol nutritional supplement in the prevention of gestational diabetes: a pilot placebo controlled double blind randomised trial.

MERIT- Prevention of progression to type 2 diabetes in women with gestational diabetes: A feasibility study for a randomised trial on a Mediterranean diet.

OMAHA- Optimising health outcomes by using Metformin to reduce risk of diabetes After pregnancy: a feasibility study for a randomised, blinded, placebo-controlled trial

TILTTime-Lapse Imaging Trial - A pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time lapse imaging in in-vitro fertilisation treatment.

COVIpreg - COVID-19 infection in pregnancy; A prospective cohort study of immunological response and long-term maternal morbidity. 

 

PrePro- Probiotics in the prevention of preterm birth - pilot randomised trial. This is a Barts Charity funded feasibility trial to determine the biological effects of probiotics on the vaginal flora and examine the components that will be essential to the success of a double-blinded, placebo-controlled randomised trail (RCT) on the effects of oral probiotics administered daily from early pregnancy on the risk of pre-term birth. 

GBS2- GBS2 is a cluster randomised trial designed to investigate the real time accuracy of a rapid PCR test to detect GBS colonisation among women in labour with risk factors. GBS2 will also evaluate if using this rapid intrapartum test for GBS colonisation reduces maternal and neonatal antibiotic usage compared with the usual care of Intrapartum Antibiotic Prophylaxis (IAP) based on maternal risk factors alone. We aim to recruit a minimum of 8 clusters per arm (total 16 hospitals), from which we estimate 84 women with risk factors will be recruited.

MEMPHIS- The RfPB funded randomised, feasibility trial  aims to identify if a smart phone app that delivers psychological approaches can help women with chronic pelvic pain.

GIFTS - Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples

SALVO- A randomised controlled trial of intra-operative cell salvage during caesarean section in women at risk of haemorrhage

ESTEEM- Effect of simple, targeted diet in pregnant women with metabolic risk factors on pre-eclampsia. A randomised trial. 

IPPIC- Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of pre-eclampsia: an Individual Patient Data (IPD) Meta-analysis

HABselect (Leeds) - Selection of sperm for Assisted Reproductive Treatment by prior hyaluronic acid binding: increasing live birth outcomes and reducing miscarriage rates (Hyaluronic Acid Binding Sperm Selection; HABSelect).

TABLET (Birmingham) - Efficacy and mechanism of thyroxine treatment on pregnancy and neonatal outcomes in women with thyroid antibodies: A randomised, placebo-controlled, double-blind, multi-centre trial [The TABLET (Thyroid AntiBodies and LEvoThyroxine) Trial]

EMPiRE Antiepileptic drug (AED) management in Pregnancy: An evaluation of effectiveness, cost effectiveness and acceptability of dose adjustment strategies

MEDAL- Can magnetic resonance imagining (MRI) scan replace or triage the use of laparoscopy in establishing a diagnosis among women presenting in secondary care with chronic pelvic pain (CPP)?

PREP - Development and validation of a prediction model for risk of complications in early onset pre-eclampsia  

iWIP IPD M-A - Effects of weight management interventions on maternal and fetal outcomes in pregnancy: Individual patient data (IPD) meta-analysis of randomised trials and model based economic evaluation

EBM Connect - Evidence-based Medicine Collaboration Network for guideline development, teaChing and dissemination

Cervical Cancer (PET CT) - Clinical effectiveness of PET-CT imaging in restaging recurrent cervical cancer: Systematic review of evidence and economic modelling

Obesity in Pregnancy - Interventions to reduce or prevent obesity in pregnant women: A systematic review of evidence synthesis (Obesity  in pregnancy)

Vulval Cancer (Sentinel Node) - Sentinel lymph node (SLN) status in vulval cancer: Systematic quantitative reviews and decision analytic model based economic evaluation

BUS (Birmingham) - Accuracy of Bladder Ultrasound (BUS) in the diagnosis of Detrusor Overactivity: a study to evaluate if ultrasound can reduce the need for urodynamics

PLUTO (Birmingham) - Percutaneous Shunting in Bladder Outlet Obstruction Trial

STAMP (Edinburgh) - (A Proof of Principle, Double-Blind, Randomised Placebo-Controlled, Multi-Centre Trial of pravaStatin to Ameliorate Early Onset Pre-eclampsia)

DAPPA - How accurate is spot urinary protein: creatinine ratio (SPCr) and spot albumin:creatinine ratio (SACr) compared to 24-hour protein estimation to assess women with hypertensive disease in pregnancy (HDP) after 24 weeks gestation.

Katie’s Team – The women’s health research patient and public advisory group for East London.

“Katie’s Team” is the KT Network patient and public advisory group. It consists of mums and local members of the public who have a connection to our research areas of childbirth, pregnancy and reproductive issues.

What do we do?

We meet face to face 3 times a year to comment on specific research questions, to advise on the direction of the research, and to learn more about how research in women’s health is conducted. For example, Katie’s Team members have advised on how to reach women who had diabetes in pregnancy for follow-up studies; or given their opinion on what the relevant outcomes were for pregnant women who were anaemic; or commented on learning materials that are used to spread the word about research.

Why do it?

The purpose of the group is to ensure that women’s health research is done effectively and remains relevant to the needs of local mothers. That’s because women who have experienced pregnancy and childbirth issues have unique insight that is valuable to the researchers. “Katie’s Team” members also act as champions for research within their own communities.

Who can join?

Anyone with a personal experience of childbirth, pregnancy or reproductive issues, and their partners or family members. We particularly welcome members from East London.  If you live outside of London, you are welcome to join our mailing list – we also send out electronic newsletters every few months with updates and involvement opportunities.

Get in touch on ktnetwork@qmul.ac.uk, and we can send you a role description and further information. You can also find more information on our website https://www.barc-research.org/katies-team 

Katherine Twining Research Network 

The Katherine Twining Network aims to facilitate multidisciplinary research in reproductive health and childbirth, providing leadership in development and delivery of women’s health studies. It is named after the first Matron and founder of the Plaistow Maternity Hospital (established in 1889 as St Mary's District Nurses' Home). Its services are currently delivered through the maternity provision at Newham General Hospital.

This initiative aims to bring together doctors, nurses, midwives and scientists working towards improvement in women's health in East London and beyond.

Katherine Twining Network supports and actively encourages the involvement in trainees in research. This includes the provision of academic training, supervision of MD and PhD students, and involvement of clinical trainees in ongoing research activities. We support the establishment of a trainee-led network that improves research literacy and trainee participation in research. This will be provided through our online website where trainees can complete EBM e-learning packages, access databases with research opportunities and learn about how to organise out of programme placements. Along with online resources, it will provide a network for those trainees already involved in research or interested in exploring the world of academic medicine.

See more information about the Katherine Twining: