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Institute of Health Sciences Education - Faculty of Medicine and Dentistry
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Dr John Broad

Lecturer in Medical Sciences

Email: j.broad@qmul.ac.uk

Profile

The major part of John Broad's current role is to design and lead physiology and anatomy sessions for Phase 1 students (including GEP and PA students). He also leads the Practical Enrichment sessions in year 1 of the MBBS course. His teaching interests are based around pharmacology, gastroenterology and neuroscience. Prior to his recent return to the London campus, John Broad was the head of year 1 in QMUL Malta, and led the physiology teaching. He was the Malta module lead for Brain and Behaviour, and for the Human Science and Public Health modules.

John Broad is the Deputy Head of SSCs and Electives for years 3 - 5. 

Before starting his teaching career, John Broad was a post-doctoral researcher based in The Centre for Neuroscience and Trauma. He specialised in human tissue gastrointestinal neuropharmacology.

Teaching

John Broad is the co-lead for the GEP Brain and Behaviour course, and the GEP Principal Internal Examiner. He also acts as a senior tutor for year 1, and a MedPro supervisor. He currently supervises two SSC 4 projects, and two intercalated Medical Education projects. 

Research

Research Interests:

My research interests as a post-doctoral researcher were in the field of neurogastroenterology. I am actively researching the teaching of pharmacology to medical students.

Publications

Full papers

  • Broad J, Kung VWS, Palmer A, Elahi S, Karami A, Darreh-Shori T, Ahmed S, Thaha MA, Carroll R, Chin-Aleong J, Martin JE, Saffrey MJ, Knowles CH, Sanger GJ. Changes in neuromuscular structure and functions of human colon during ageing are region-dependent. Gut. 2019 Jul;68(7):1210-1223
  • McGuire C, Boundouki G, Hockley JRF, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. Ex vivo study of human visceral nociceptors. Gut. 2018 Jan;67(1):86-96.
  • Broad J, Maurel D, Kung VW, Hicks GA, Schemann M, Barnes MR, Kenakin TP, Granier S, Sanger GJ. Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design. Sci Rep. 2016 Aug 5;6:30797.
  • Broad J, Takahashi N, Tajimi M, Sudo M, Góralczyk A, Parampalli U, Mannur K, Yamamoto T, Sanger GJ. RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions. J Pharmacol Sci. 2016 Feb;130(2):60-5.
  • Broad J, Callaghan B, Sanger GJ, Brock JA, Furness JB. Analysis of the ghrelin receptor-independent vascular actions of ulimorelin. Eur J Pharmacol. 2015 Apr 5;752:34-9
  • Broad J, Hughes F, Chin-Aleong J, Sifrim D, Sanger GJ Regionally-dependent neuromuscular activity caused by motilin and 5-HT4 receptor activation in human isolated distal esophagus and gastric fundus Neurogastroenterol Motil. 2014 Sep;26(9):1311-22.
  • Broad J, Góralczyk A, Mannur K, Dukes GE, Sanger GJ. Drugs acting at 5-HT4, D­2, motilin and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach. Neurogastroenterol Motil. 2014 Jun;26(6):851-61.
  • Broad J, Kung VW, Boundouki G, Aziz Q, De Maeyer JH, Knowles CH, Sanger GJ. Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility. Br J Pharmacol. 2013 Nov;170(6):1253-61
  • Broad J, Sanger GJ The antibiotic azithromycin is a motilin receptor agonist in human stomach: Comparison with erythromycin. Br J Pharmacol. 2013 Apr;168(8):1859-6
  • Broad J, Mukherjee S, Samadi M, Martin JE, Dukes GE, Sanger GJ Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists. Br J Pharmacol. 2012 Oct;167(4):763-74
  • Javid FA, Bulmer DC, Broad J, Aziz Q, Dukes GE, Sanger GJ. Anti-emetic and emetic effects of erythromycin in Suncus murinus: Role of vagal nerve activation, gastric motility stimulation and motilin receptors.  Eur J Pharmacol. 2013 Jan 15;699(1-3):48-54
  • Leming S, Broad J, Cozens SJ, Otterson M, Winchester W, Lee K, Dukes GE, Sanger GJ. GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal motility in conscious dogs Neurogastroenterol Motil. 2011 Oct 23(10):958-e410
  • McNair, K, Broad, J., Riedel, G., Davies, C. H., Cobb, S. R. Global changes in the hippocampal proteome following exposure to an enriched environment Neuroscience 2007 145, P413-422
  • Sanger GJ, Broad J, Andrews PL. The relationship between gastric motility and nausea: gastric prokinetic agents as treatments. Eur J Pharmacol. 2013 Sep 5;715(1-3):10-4
  • Sanger GJ, Broad J, Kung V, Knowles CH Translational neuropharmacology: the use of human isolated gastrointestinal tissues. Br J Pharmacol. 2013 Jan;168(1):28-43
  • Sanger GJ, Wang Y, Hobson A, Broad J. Motilin: Toward a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists. Br J Pharmacol. 2012 Nov 28

Review Articles

 

Book Chapters

  • Sanger GJ, Broad J, Callaghan B, Furness JB. Ghrelin and Motilin Control Systems in GI Physiology and Therapeutics. Handb Exp Pharmacol. 2017;239:379-416.
  • Sanger GJ, Broad J, Alpers DH. Peptide Drug Discovery and Development: Translational Research in Academia and Industry, First Edition. Edited by Miguel Castanho and Nuno C. Santos. (P269-94), 2011
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