Institute of Health Sciences Education - Barts and The London

Dr Rachel Ashworth

Rachel

Senior Lecturer in Medical Science

Email: r.ashworth@qmul.ac.uk
Telephone: +44 20 7882 2613
Room Number: 3.17 Garrod Building, Turner Street, Whitechapel, London E1 2AD

Profile

Rachel Ashworth is a Senior Lecturer and lead in physiology in the School of Medicine and Dentistry (SMD). She is a Senior Fellow of the Higher Education Academy and a member of the Physiological Society. She was awarded her Postgraduate Certificate in Academic Practice (PGCAP) in 2008 and is currently studying a Masters in Clinical Education at Queen Mary, University of London.

She has a long-standing interest in Physiology, with a particular interest in the integration between health science and clinical practice. She co-ordinates Physiology teaching across Part 1 of the medical curriculum, MBBS and GEP programmes, with a focus on delivering and developing the practical teaching. In addition she has held a number of positions in assessment, including internal (BDS and MBBS degree programmes, QMUL) and external in various UK medical schools within the UK.

She trained as a laboratory scientist, completing her PhD (Biochemistry and Physiology) at the University of Reading and worked as postdoctoral researcher at the University of Rochester, New York, USA. Subsequently, she took up a position at University College London and was a David Philips BBSRC fellow (2000-2006). Her research interests include cell signalling, most recently in the development of skeletal muscle, using the zebrafish as a model.

Research

Publications

Mazelet, L., Parker, M. O., Li, M., Arner, A., & Ashworth, R. (2016). Role of Active Contraction and Tropomodulins in Regulating Actin Filament Length and Sarcomere Structure in Developing Zebrafish Skeletal Muscle.. Front Physiol, 7, 91. doi:10.3389/fphys.2016.00091

Papadopoulou, M. V., Bloomer, W. D., Rosenzweig, H. S., Ashworth, R., WILKINSON, S. R., Kaiser, M., . . . Rodriguez, A. (2013). Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential  anti-Chagasic  drugs:  In vivo studies. Future Medicinal Chemistry, 5(15), 1763-1776. doi:10.4155/fmc.13.108

de Paula, W. B. M., Agip, A. -N. A., Missirlis, F., Ashworth, R., Vizcay-Barrena, G., Lucas, C. H., & Allen, J. F. (2013). Female and male gamete mitochondria are distinct and complementary in transcription, structure, and genome function.. Genome Biol Evol, 5(10), 1969-1977. doi:10.1093/gbe/evt147

Buchanan-Kilbey, G., Djumpah, J., Papadopoulou, M. V., Bloomer, W., Hu, L., WILKINSON, S. R., & Ashworth, R. (2013). Evaluating the developmental toxicity of trypanocidal nitroaromatic compounds on zebrafish. Acta Tropica, 128(3), 701-705. doi:10.1016/j.actatropica.2013.07.022

Ashworth, R. (2012). Redundancies at Queen Mary,University of London.. Lancet, 379(9834), 2338-2339. doi:10.1016/S0140-6736(12)61013-7

Prodromou, N. V., Thompson, C., Osborn, D. P., Cogger, K. F., Ashworth, R., Knight, M. M., . . . Chapple, J. P. (2012). Heat shock induces rapid resorption of primary cilia. Journal of cell science, 4297-4305. doi:10.1242/jcs.100545

Wu, H. H., Brennan, C., & Ashworth, R. (2011). Ryanodine receptors, a family of intracellular calcium ion channels, are expressed throughout early vertebrate development.. BMC Res Notes, 4, 541. doi:10.1186/1756-0500-4-541

Wu, H. H. -T., Brennan, C., & Ashworth, R. (2009). A Novel Role for Ryanodine Receptors during Embryonic Development: Studies in Zebrafish.. In JOURNAL OF GENERAL PHYSIOLOGY Vol. 134 (pp. 17A). Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000267442100051&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a

Lahne, M., Krivcevska, C., & Ashworth, R. (2009). A Contraction-dependent Pathway Regulates Myofibril Organization during Skeletal Muscle Development In Vivo.. In JOURNAL OF GENERAL PHYSIOLOGY Vol. 134 (pp. 4A). Retrieved from http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000267442100019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6a

Hawkins, T. A., Haramis, A. -P., Etard, C., Prodromou, C., Vaughan, C. K., Ashworth, R., . . . Wilson, S. W. (2008). The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis.. Development, 135(6), 1147-1156. doi:10.1242/dev.018150

ASHWORTH, R. J., Patel, S., Koh, K. R., Devogelaere, B., Fabes, J., Tunwell, R. E., & De Smedt, H. (2007). Molecular and Functional Characterization of Inositol Trisphosphate Receptors during Early Zebrafish Development. Journal of Biological Chemistry, 282(19), 13984-13993. doi:10.1074/jbc.M700940200

Brennan, C., Mangoli, M., Dyer, C., & ASHWORTH, R. J. (2005). Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo. The Journal of Cell Science, 118(Pt 22), 5181-5190. doi:10.1242/jcs.02625

Ashworth, R., & BRENNAN, C. H. (2005). Use of transgenic zebrafish reporter lines to study calcium signalling in development. Briefings in Functional Genomics and Proteomics, 4(2), 186-193. doi:10.1093/bfgp/4.2.186

Ashworth, R. (2004). Approaches to measuring calcium in zebrafish: focus on neuronal development.. Cell Calcium, 35(5), 393-402. doi:10.1016/j.ceca.2004.01.002

Ashworth, R. (2004). Approaches to measuring calcium in zebrafish: focus on neuronal development. CELL CALCIUM, 35(5), 393-402. doi:10.1016/j.ceca.204.01.002

ASHWORTH, R. J., & Bolsover, S. R. (2002). Spontaneous activity-independent intracellular calcium signals in the developing spinal cord of the zebrafish embryo. Developmental Brain Research, 139(2), 131-137. doi:10.1016/S0165-3806(02)00538-2

ASHWORTH, R. J., Zimprich, F., & Bolsover, S. R. (2001). Buffering intracellular calcium disrupts motoneuron development in intact zebrafish embryos. Developmental Brain Research, 129(2), 169-179. doi:10.1016/S0165-3806(01)00198-5

ASHWORTH, R. J., Koh, K. R., Tunwell, R., Patel, S., & Fabes, J. (n.d.). Role of IP3 Receptors during Early Zebrafish Development.. Journal of Biological Chemistry.