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The Science of Biocompatibility (MAT6312)

Dept. responsible. School of Engineering and Material Sciences (SEMS), QMUL

Course organiser.

Dr K. Hing,

To develop an understanding of the concept that chemistry, structure and mechanics combine to contribute to a materials success or failure in clinical applications.   Developing the ability to strategically evaluate what comprises biocompatibility and the most appropriate techniques for its assessment is essential in this field.

Topics include: This module will provide a comprehensive understanding of the concepts related to biocompatibility. It will cover topics including proteins and protein adsorption, cells and tissue interactions (attachment, fluid shear and mechanotransduction), biomaterial blood and cell interactions, inflammation, wound healing and foreign body response and toxicity, hypersensitivity and infection.

The In-vitro testing of biomaterials will be considered with respect to 
– chemical exchange and degradation 
– cell response (proliferation vs differentiation)
– evaluation of material compatibility
– evaluation of device functionality (biomechanics, remodelling/adaptation)
Matters related to clinical trials and regulatory approval will be considered including clean manufacturing, microbiology, packaging and sterility assurance.

Impart a knowledge and understanding of:

1. The concept that biocompatibility is application dependent

2. The range and complexity of biological responses to a material/device/restoration

3. The range of effects that the physiological environment can have on material/device/restoration functionality

4. The methods used to assess biocompatibility and associated ethics

Promotion of intellectual skills to:

1. Appreciate the wide range of material characteristics and host interactions/responses that control biocompatibility

2. Identify which materials properties are critical to biocompatibility in a given application

3. Recognise the limitations of measurement and experimental techniques used in the study of biocompatibility

Facilitate transferable skills able to:

1. Communicate knowledge and ideas verbally and in written reports using a vocabulary of biomedical terms.

2. Recognise, analyse and solve problems individually and in groups

Examination 100% (one 2.5hr examination)

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