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Inflammation and Special Topics in Pathology (ICM6022)

Dept. responsible. Pathology Unit, Blizard Institute and William Harvey Research Institute

Course organisers:

Dr Jurgen Groet,

Dr Dianne Cooper,

Inflammation is central to many disorders, and chronic inflammatory diseases are a major source of disability. The module will examine the scope of inflammatory disorders, the causes of inflammation, how to treat it and how it should be assessed, both experimentally and clinically. The principal aim is to understand the mechanisms and treatments of common chronic inflammatory disorders. The module will also cover a variety of additional topics in pathology. Material covered in many of the lectures will reflect the research interests of the speakers, and will include such diverse subjects as gastro-intestinal and genito-urinary tumours, and ageing and oncogenes.

Topics include: overview of inflammation, mechanisms of inflammatory pain, animal models of inflammation, gene and protein therapies based on animal studies, mediators of inflammation, regulation of acute inflammation, mechanisms of auto-immune disease, and neuro-endocrine immune regulation of inflammation. Special topics may include testicular and prostatic tumours, and pathology of the bladder and GI system.

This is a taught module delivered by lectures. The content includes the mechanisms of the inflammatory response, including how the response is initiated, what molecules drive this process and which cell types are involved. The role of inflammation in several pathologies including diabetes, rheumatoid arthritis, cancer, inflammatory bowel disease and transplant rejection are covered. Lectures are given on the use of anti-inflammatory therapeutic agents (NSAIDs, steroids and biological therapies) and their mechanisms of action. Students will be able to describe experimental models used to investigate both the mechanisms of inflammation and the development of new therapeutic drugs. 

The main aim of this module is to understand the pathogenesis of inflammatory disease. The module offers students the opportunity to see how the theoretical ideas concerning the causes of acute and chronic inflammation are applied to the understanding of common forms of inflammatory disease. It allows them to explore aspects of the subject to a greater depth than is normally possible in the clinical course. It also explores topics in pathology and the role of pathologists to help students understand this branch of medicine.

Examination 100%

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