Professor Adrian Martineau, B Med Sci DTM&H MRCP PhD FRSB
Clinical Professor of Respiratory Infection and Immunity
Email: email@example.comTelephone: 020 7882 2551
Adrian gained a B Med Sci degree in Epidemiology and Public Health from Newcastle University in 1995, and graduated from Newcastle Medical School in the following year. He then gained a Diploma in Tropical Medicine and Hygiene from Liverpool University before working as a Medical Officer in South Africa. He returned to Liverpool to continue medical training in 1999, and became a member of the Royal College of Physicians in 2001. Adrian joined Queen Mary as a lecturer in Respiratory Medicine in 2002, and established a programme of laboratory and clinical research into the immunomodulatory actions of vitamin D in tuberculosis. He received his PhD in 2010, and is currently conducting clinical trials of vitamin D supplementation to prevent respiratory infections and non-communicable diseases in the UK, South Africa and Mongolia. He was elected a Fellow of the Royal Society of Biology in 2017.
I chair the steering committee for the ARREST trial (Multicentre trial of adjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia).
Vitamin D Podcast, Wellcome Collection
Adrian's primary research interest is in the effects of vitamin D on human health. His work combines laboratory investigation of the effects of vitamin D on the immune system with a series of multi-centre clinical trials and meta-analyses, investigating the potential role of vitamin D supplementation as an agent to prevent respiratory infections and non-communicable diseases.He is clinical Chief Investigator for the Vitamin D and Longevity trial (VIDAL, a NIHR-funded study investigating effects of vitamin D supplementation on all-cause mortality in UK adults aged 65-84 years) and the ViDiKids trial (a MRC-funded study investigating whether vitamin D can prevent tuberculosis infection among primary schoolchildren in Cape Town, South Africa). He sits on the NICE Public Health Advisory Committee on Vitamin D, and works clinically in the Tuberculosis Clinic at Barts Health NHS Trust.
Adrian has an active PhD programme and enquiries from prospective PhD or MD students interested in respiratory infection and / or vitamin D are welcome.
Ad hoc postgraduate teaching
Undergraduate teaching (PBL and OSCEs)
Topics for PhD supervision:
- ViDiKids trial, Cape Town: https://clinicaltrials.gov/ct2/show/NCT02880982
- ViDiKids trial, Ulaanbaatar: https://clinicaltrials.gov/ct2/show/NCT02276755
- Trial of adjunctive vitamin D in tuberculosis treatment, Ulaanbaatar: https://clinicaltrials.gov/ct2/show/NCT01657656
- Trial of vitamin D in the treatment of severe acute malnutrition: https://clinicaltrials.gov/ct2/show/NCT03170479
- ResolveD-TB trial, London: https://clinicaltrials.gov/ct2/show/NCT03011580
- ResolveD-CAP trial, London: https://clinicaltrials.gov/ct2/show/NCT02802722
- OptiVit study, London: https://clinicaltrials.gov/ct2/show/NCT02880930
- Meta-analysis of RCTs of vitamin D to prevent acute respiratory infections and exacerbations of asthma and COPD: http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42014013953
- Meta-analysis of RCTs of vitamin D to enhance response to tuberculosis treatment: http://www.crd.york.ac.uk/prospero/display_record.asp?src=trip&ID=CRD42015020288
- Evaluation of a novel microbiological diagnostic test for latent TB infection in Ethiopia:http://gtr.rcuk.ac.uk/projects?ref=MR%2FP024548%2F1
Ganmaa D, Munkhzul B, Fawzi W, Spiegelman D, Willett WC, Bayasgalan P, Baasansuren E, Buyankhishig B, Oyun-Erdene S, Jolliffe DA, Xenakis T, Bromage S, Bloom BR, Martineau AR. High-Dose Vitamin D3 During Tuberculosis Treatment in Mongolia: A Randomised Controlled Trial. Am J Respir Crit Care Med. 2017 Jul 10. doi: 10.1164/rccm.201705-0936OC. [Epub ahead of print]
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, Esposito S, Ganmaa D, Ginde AA, Goodall EC, Grant CC, Griffiths CJ, Janssens W, Laaksi I, Manaseki-Holland S, Mauger D, Murdoch DR, Neale R, Rees JR, Simpson S Jr, Stelmach I, Kumar GT, Urashima M, Camargo CA Jr. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017 Feb 15;356:i6583. doi: 10.1136/bmj.i6583.
Martineau AR, Cates CJ, Urashima M, Jensen M, Griffiths AP, Nurmatov U, Sheikh A, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016 Sep 5;9:CD011511. [Epub ahead of print]
Martineau AR, Hanifa Y, Witt KD, Barnes NC, Hooper RL, Patel M, Stevens N, Enayat Z, Balayah Z, Syed A, Knight A, Jolliffe DA, Greiller CL, McLaughlin D, Venton TR, Rowe M, Timms PM, Clark D, Sadique Z, Eldridge SM, Griffiths CJ. Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu). Thorax. 2015 Oct;70(10):953-60. doi: 10.1136/thoraxjnl-2015-206996. Epub 2015 Jun 10.
Coussens AK, Wilkinson RJ, Martineau AR. Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3. PLoS Pathog. 2015 Jul 2;11(7):e1005007. doi: 10.1371/journal.ppat.1005007. eCollection 2015 Jul.
Martineau AR, MacLaughlin BD, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, Kilpin K, McLaughlin D, Fletcher G, Mein CA, Hoti M, Walton R, Grigg J, Timms PM, Rajakulasingam RK, Bhowmik A, Rowe M, Venton TR, Choudhury AB, Simcock DE, Sadique Z, Monteiro WR, Corrigan CJ, Hawrylowicz CM, Griffiths CJ. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax. 2015 May;70(5):451-7. doi: 10.1136/thoraxjnl-2014-206449. Epub 2015 Feb 27.
Martineau AR, James WY, Hooper RL, Barnes NC, Jolliffe DA, Greiller CL, Islam K, McLaughlin D, Bhowmik A, Timms PM, Rajakulasingam RK, Rowe M, Venton TR, Choudhury AB, Simcock DE, Wilks M, Degun A, Sadique Z, Monteiro WR, Corrigan CJ, Hawrylowicz CM, Griffiths CJ. Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2015 Feb;3(2):120-130. doi: 10.1016/S2213-2600(14)70255-3. Epub 2014 Dec 2.
Coussens AK, Wilkinson RJ, Hanifa Y, Nikolayevskyy V, Elkington PT, Islam K, Timms PM, Venton TR, Bothamley GH, Packe GE, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Mein CA, Bhaw-Rosun L, Nuamah R, Young DB, Drobniewski FA, Griffiths CJ, Martineau AR. Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment. Proc Nat Acad Sci USA 2012 Sep 18;109(38):15449-54.
Martineau AR. Bolus-dose vitamin D to prevent infant pneumonia. Lancet 2012 Apr 14;379(9824):1373-5.
Lowe DM, Redford PS, Wilkinson RJ, O’Garra A, Martineau AR. Neutrophils and tuberculosis: a double-edged sword? Trends Immunol 2012;33(1):14-25
Martineau AR, Nhamoyebonde S, Oni T, Rangaka MX, Marais S, Bangani N, Tsekela R, Bashe L, de Azevedo V, Caldwell J, Venton TR, Timms PM, Wilkinson KA, Wilkinson RJ. Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa. Proc Nat Acad Sci USA 2011;108(47):19013-7
Martineau AR, Timms PM, Bothamley GH, Hanifa Y, Islam K, Claxton AP, Packe GE, Moore-Gillon JC, Darmalingam M, Davidson RN, Milburn HJ, Baker LV, Barker RD, Woodward NJ, Venton TR, Barnes KE, Mullett CJ, Coussens AK, Rutterford CM, Mein CA, Davies GR, Wilkinson RJ, Nikolayevskyy V, Drobniewski FA, Eldridge SM, Griffiths CJ. High-dose vitamin D3 during intensive phase treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011;15:377:242-50
Martineau AR, Newton, SM, Wilkinson KA, Kampmann B, Hall BR, Nawroly N, Packe GE, Davidson RN, Griffiths CJ, Wilkinson RJ. Neutrophil-mediated innate immune resistance to mycobacteria. J Clin Invest 2007;117:1988-94
Martineau AR, Wilkinson KA, Newton SM, Norman AW, Packe GE, Skolimowska K, Davidson RN, Kampmann B, Griffiths CJ, Wilkinson RJ. Interferon gamma- and tumour necrosis factor-independent vitamin D-inducible human suppression of mycobacteria by cathelicidin LL-37. J Immunol 2007;178:7190–7198
Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, Packe GE, Davidson RN, Eldridge SM, Maunsell ZJ, Rainbow SJ, Berry JL, Griffiths CJ. A single dose of vitamin D enhances immunity to mycobacteria. Am. J Respir. Crit Care Med 2007;176:208-13
View all Adrian Martineau's Research Publications at: http://www.researchpublications.qmul.ac.uk
Post-doctoral Research Associates:
Dr David Jolliffe
Dr Mulugeta Belay
Dr Julie Demaret
Dr Alicia Yeap
Mr Christos Stefanidis
Dr Jonathan Mayito
Dr Jennifer Roe