Dr Ute-Christiane Meier, DPhil (Oxon), Diplom –Biol, Dr. med. habil.
Lecturer in Neuroimmunology
Centre: Centre for Neuroscience, Surgery and Trauma
Email: email@example.comTelephone: 020 7882 2318
2018 Visiting lecturer at Institute of Psychiatry, Psychology and Neuroscience, Kings College, London, UK
2014 Habilitation at Ludwig-Maximilians University Munich and Blizard Institute, Queen Mary University of London, UK
2012 Lecturer and Group Leader, Blizard Institute, London, UK
2007 Senior Postdoc at Blizard Institute, London, UK
2000-2006 Postdoctoral Scientist at Oxford University, British Biotech, Oxford, Edward Jenner Institute of Vaccine Research, Compton, UK
2000 DPhil Molecular Medicine, University of Oxford “Cytotoxic T-cell recognition of HIV-1 reverse transcriptase: the effect of mutation within this protein on immune recognition and enzyme function”
1992 Diplom Biology, Heidelberg University, Germany
Problem-based learning facilitator
BSc Neuroscience (Intercalated) - lab project supervisor
MSc Neuroscience and Translational Medicine - lab project supervisor
Student selected component – viral immunology, neuroinflammation
Topics for PhD supervision: Neuroinflammation and Immunopsychiatry
Lecture Brain and Mind, Perspective on Brain Disorders: Inflammation in Neuropsychiatric Disease
The interaction between a pathogen and the host has to be very well orchestrated by a fine tuned immune system to avoid immunopathology, autoimmunity and chronic inflammation. My special interest is the interaction between the host, the immune system and the environment in multiple sclerosis and neuropsychiatric disease.
The aetiology of multiple sclerosis (MS) is as yet poorly understood and disease causing mechanisms are still unknown. One of our project focusses on molecular mimicry as one potential trigger of MS. Remnants of ancient retroviruses in the human genome, termed human endogenous retroviruses (HERV), and Epstein-Barr virus (EBV) infection are associated with MS. Our findings revealed the potential pathogenic role of molecular mimicry between endogenous retroviruses, EBV and brain proteins. This project is performed in collaboration with Prof Ramasamy with the support of a MS-Society Breakthrough Award (USA).
I was appointed as visiting lecturer at the Institute of Psychiatry, Psychology and Neuroscience, Kings College London in 2018 and established a research program looking into autoimmune/autoinflammatory aspects and the role of environmental risk factors in schizophrenia and other neuropsychiatric diseases, a novel and exciting area in immunopsychiatry.
Ramasamy R, Mohammed F, Meier UC. HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis (2020). Imm Letters, 217:15-24
Disanto G, Zecca C, MadLachlan S, Sacco R, Handunnetthi L, Meier UC, Simpson A, McDonald L, Rossi A, Benkerkt P, Kuhle J, Ramagopalan SV, Gobbi C. Prodromal symptoms of multiple sclerosis in primary care (2018). Ann Neurol 83(6): 1162-1173
Kočovská E, Gaughran F, Krivoy A and Meier UC. Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism (2017). Front. Psychiatry 8:47. doi: 10.3389/fpsyt.2017.00047
Sisay S, Lorenza-Lopez L, Warnes G, Quiroga-Fernández A, Palace J, Alvarez Lafuente R, Dua P, Meier UC. Untreated relapsing remitting multiple sclerosis patients show antibody production against latent Epstein Barr Virus (EBV) antigens mainly in the periphery and innate immune IL-8 responses preferentially in the CNS (2017). J Neuroimmunol. 15;306:40-45