Dr Xuenong Bo, MB, MSc, PhD
Non-clinical Senior Lecturer in Neurosurgery
Centre: Neuroscience and Trauma
Email: firstname.lastname@example.orgTelephone: 020 7882 2294
Xuenong Bo's main research direction is on neural repair after spinal cord injury, using viral vector mediated gene-targeting techniques and cell transplantation. He has also been studying the roles of extracellular ATP and purinoceptors in the pathophysiological mechanisms of nerve injury and developing treatments for nerve injury.
Xuenong Bo was awarded a Bachelor of Medicine and an MSc in Pharmacology in China. He joined the Department of Anatomy and Developmental Biology in University College London (UCL) as a Visiting Scientist in 1987 and was awarded a PhD in Neurobiology in 1992, supervised by Professor Geoffrey Burnstock (FRS). He continued to work as a Research Fellow and then a Senior Research Fellow in UCL. He also worked as a Visiting Fellow in the lab of Professor Eric Barnard (FRS) in the MRC Laboratory of Molecular Biology in Cambridge for two years. From 1995 to 2001 he mainly carried out his lab work in the Wellcome Laboratory for Molecular Pharmacology in UCL. In 2001 he moved to the Institute of Molecular Physiology in the University of Sheffield, headed by Professor Alan North (FRS). In 2002 he was appointed as a Non-Clinical Lecturer in the Academic Department of Neurosurgery in Barts and the London School of Medicine and Dentistry, and promoted to Senior Lecturer in 2008.
Honorary Professor of the Third Military Medical University, China.Member of Genomic Modification Committee of Queen Mary University of London
MBBS, Intercalated BSc in Neuroscience, BSc in Neuroscience
Before joining Queen Mary University of London (QMUL), his main research interest was on the characterization and molecular cloning of ATP receptors. After the appointment in QMUL, he shifted his research focus to promoting axonal regeneration of injured neurons using gene-targeting techniques. The strategies used include targeting the signalling pathways of axon growth inhibitors, modifying the CNS environment by viral vector-mediated expression of polysialic acid, transplanting genetically modified Schwann cells into the injured CNS. He also studied the involvement of extracellular ATP and its receptors in nerve injury and repair. Recently he started to study the involvement of microglia in neuronal death in an animal model of multiple sclerosis, in neuropathic pain, and in conditioning effect on axonal regeneration.
Dr. Svetlana Gushchina, Senior Research Associate
Dr. Yi Zhang, Honorary Senior Lecturer
Wu D, Lee S, Luo J, Xia H, Gushchina S, Richardson PM, Yeh J, Krügel U, Franke H, Zhang Y, Bo X. (2017) Intraneural injection of ATP stimulates regeneration of primary sensory axons in the spinal cord. Journal of Neuroscience (in press).
Zhang Y, Gao F, Wu D, Moshayedi P, Zhang X, Ellamushi H, Yeh J, Priestley JV, Bo X. (2013) Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration. Neurobiology of Disease 58: 270-280.
Wu D, Yang P, Zhang X, Luo J, Haque ME, Yeh J, Richardson PM, Zhang Y, Bo X. (2009) Targeting a dominant negative Rho kinase to neurons promotes axonal outgrowth and partial functional recovery after rat rubrospinal tract lesion. Molecular Therapy. 17: 2020-2030.
Zhang Y, Zhang X, Wu D, Verhaagen J, Richardson PM, Yeh J, Bo X. (2007) Lentiviral-mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cord. Molecular Therapy. 15: 1796-1804.
Zhang Y, Bo X, Schoepfer R, Holtmaat AJDG, Verhaagen J, Emson PC, Lieberman AR, Anderson PN. (2005) GAP-43 and L1 act synergistically to promote regeneration of Purkinje cell axons in vivo. Proceedings of the National Academy of Sciences of USA. 102: 14883-14888.
View all Xuenong Bo's Research Publications at: http://www.researchpublications.qmul.ac.uk