Dr Vincent Cibert-Goton
Dr Vincent Cibert-Goton is an electrophysiologist at Queen Mary University of London. He obtained his PhD in Neuroscience from King’s College London in 2011 and has since been a member of staff at the QMUL Blizard Institute. He is qualified in in vivo and in vitro neurophysiology using extra cellular or patch clamp techniques.
Vincent’s research interests lie in the processing of sensory information (pain sensing) from the gastrointestinal tract in normal and disease states (IBS, IBD) and in the development of novel pharmacological interventions for future treatments. He uses a range of in vitro visceral sensory nerve recording techniques (single and multi-units) in the mouse upper and lower GI tract (Dr David Bulmer, Prof Ashley Blackshaw) and in human intestinal preparations (Prof Charlie Knowles). Current research also includes studies of the neuropathic changes occurring in the human and mouse bowel with age.
(* leading author/co-author)
Functional and anatomical deficits lead to impaired visceral nociception with age: mechanism of silent appendicitis in the elderly? Cibert-Goton V.*, Kung V.W.S., Cian McGuire C., Hockley J.R.F., Dogra H., Tranter M., Blackshaw L.A., Knowles C.H., Belai A., Winchester W.J., Sanger G.J., Araujo E.J.A., Bulmer D.C. 2017 submitted – Gut
The Extracellular Matrix Glycoprotein, Tenascin-X Supports Gastrointestinal Sensory and Motor Function in Mice and Humans. Aktar R., et al. 2017 under revision - Gut
Histamine mediated TRPV1 sensitization drives long-term neuronal changes in post-infectious-IBS. Balemans D*, Mondelaers SU* & Cibert-Goton V*, Stakenborg N., Dooley J., Liston A., Bulmer D.C.,Vanden Berghe P., Boeckxstaens G.E., Wouters M.M. 2017 under revision - Scientific Reports
Visceral and somatic pain modalities reveal NaV 1.7-independent visceral nociceptive pathways. Hockley J et al. J Physiol. 2017 Jan 20. doi: 10.1113/JP272837.
P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. Hockley J et al. J Neurosci. 2016 Feb 24;36(8):2364-76. doi: 10.1523/JNEUROSCI.3369-15.2016.
Ex vivo study of human visceral nociceptors. McGuire C et al. Gut. 2016 Sep 21. pii: gutjnl-2016-311629. doi: 10.1136/gutjnl-2016-311629.
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome. Wouters MM, et al. Gastroenterology. 2016 Apr;150(4):875-87.e9. doi: 10.1053/j.gastro.2015.12.034.
The Activation of Serosal Nociceptors by Biopsy Supernatants From Patients With Diarrhoea Predominant Irritable Bowel Syndrome Correlates With Sensory but Not Motility Related Clinical Scores, and Is Dependent on the Functional Expression of NaV1.9. Cibert-Goton V.*, Lam C.*, Lingaya M., Spiller R., Bulmer D.C. (2016) Gastroenterology, Vol. 150, Issue 4, Pages S1-S1271 (abstract).
Vascular changes associated with spinal root avulsion injury. Cibert-Goton V*, Phillips JP, Shortland PJ. Somatosens Mot Res. 2015;32(3):158-62. doi: 10.3109/08990220.2015.1018511.
Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. Pain. 2014 Oct;155(10):1962-75. doi: 10.1016/j.pain.2014.06.015.
A1 and A2A adenosine receptor subtype selective agonists activate splanchnic colonic afferents with a clear modulatory role of NaV1.9. Cibert-Goton V.*, Hockley J , Boundouki G., Tranter M., McGuire C., Ahmed S. , Blackshaw L.A., Baker M.D., Knowles C.H., Winchester W.J , Bulmer D.C. (2013) Gastroenterology, Vol. 144 (5) - May1, 2013 (abstract).
Perfusion assessment in rat spinal cord tissue using photoplethysmography and laser Doppler flux measurements. Phillips JP, Cibert-Goton V, Langford RM, Shortland PJ. J Biomed Opt. 2013 Mar;18(3):037005. doi: 10.1117/1.JBO.18.3.037005.
Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain. Cibert-Goton V*, Yuan G, Battaglia A*, Fredriksson S, Henkemeyer M, Sears T, Gavazzi I. PLoS One. 2013;8(1):e53673. doi: 10.1371/journal.pone.0053673.