Dr Cian Mcguire
Cian gained his BSc in Sports Science and Health at Dublin City University in 2008. He then moved to London and completed his MSc in Neuroscience at the Institute of Psychiatry, Kings College London in 2010. He was awarded a PhD for his project entitled “Human Visceral Afferent Recordings: A Pre-Clinical Human Model of Visceral Pain” in 2014 by Queen Mary, University of London (QMUL). In 2014 he was appointed to a post-doctoral research fellow position focusing on the use of human visceral afferent recordings for pre-clinical drug target validation.
Cian has a particular interest in the mechanisms of pain, and how pain can be treated through pharmacological manipulation of specific receptors, and intracellular pathways. His current research projects include evaluating the efficacy of a number of potential pain relieving compounds currently under investigation by Takeda Pharmaceuticals.
Hockley JR, González-Cano R, McMurray S, Tejada-Giraldez MA, McGuire C, Torres A, WilbreyAL, Cibert-Goton V, Nieto FR, Pitcher T, Knowles CH, Baeyens JM, Wood JN, Winchester WJ, Bulmer DC, Cendán CM, McMurray G. Visceral and somatic pain modalities reveal NaV1.7-independent visceral nociceptive pathways. J Physiol 2017; 595(8):2661-2679.
McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. Ex vivo study of human visceral nociceptors. Gut 2016; [Epub ahead of print].
Hockley JR, Tranter MM, McGuire C, Boundouki G, Cibert-Goton V, Thaha MA, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, Bulmer DC. P2Y receptors sensitize mouse and human colonic nociceptors. J Neurosci 2016; 36(8):2364-2376.
Mendez DC, Stover AE, Rangel AD, Brick DJ, Nethercott HE, Torres MA, Khalid O, Wong AM, Cooper JD, Jester JV, Monuki ES, McGuire C, Le SQ, Kan SH, Dickson PI, Schwartz PH. A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I. Mol Ther Methods Clin Dev 2015; 11:2.
Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Blackshaw LA, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli. Pain 2014; 155(10): 1962-1975.