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Blizard Institute - Barts and The London

Professor David Leslie, MB BS, MRCS, MD, FRCP, FAoP

David

Professor of Diabetes and Autoimmunity

Centre: Immunobiology

Email: r.d.g.leslie@qmul.ac.uk
Telephone: 020 7882 2358
Website: Complete List of Published Work in MyBibliography: http://www.ncbi.nlm.nih.gov/pubmed/?term=leslie+rd

Profile

Richard David Leslie was elected President of the Association of Physicians of Great Britain and Ireland in 2012. He was a Wellcome Trust Senior Fellow in Clinical Science and an MRC Travelling Fellow. As Principle Investigator of three major European Union programmes (BLUEPRINT, Action LADA and EXALT) he is a leader in four areas of diabetes research, including the epigenetics and twin studies of autoimmune diabetes, nature of adult-onset autoimmune diabetes and immunotherapy of type 1 diabetes respectively. He was Founding Chairman of T1DUK, a UK national consortium, principle of Action LADA, a European consortium, Director of British Diabetic Twin Study and Director of Mendel Institute, Rome.

His international reputation is reflected in special lectures e.g. Royal College of Physicians (London), Silver Jubilee Oration (India), O’Meara Lecture (Ireland); organising and chairing international meetings e.g. NIH (USA), Danish Diabetes Academy (2014), International Immunology of Diabetes Society meeting (London 2018), 15 European Association for Study of Diabetes satellite meetings. He is Emeritus Professor to Central South University (China) and University of Rome (Italy).

He first described early environmental events as a cause of type 1 diabetes, persistent immune changes as predictors of diabetes and championed the concept of type 1 diabetes as a broad clinical, genetic and immunological spectrum in which adult-onset autoimmune diabetes is prevalent. He also first reported Genome and Epigenome Wide Association Studies in both adult-onset and childhood-onset type 1 diabetes, heritability determining haemoglobin A1c, early glucose changes in pregnancy associated with congenital malformations and early metabolic changes before the onset of type 2 diabetes.

 

 

Summary

Professsor David Leslie has been Professor of Diabetes and Autoimmunity at the Blizard Institute, University of London He has published 12 books and more than 200 peer-reviewed papers and received grants from many agencies including the EU, Wellcome Trust and MRC. In 2012 he was elected President of the Association of Physicians of Great Britain and Ireland. He ran the Diabetes Department at St Bartholomews Hospital, London with extensive experience of all aspects of diabetes, having previously been a consultant at Kings College Hospital. 

Teaching

I am Lead Professor of the International Medical Faculty at University of Rome. I also lecture on MSc courses at Queen Mary (Therapy of Inflammatory Diseases) and Kings College (Diabetes).


Research

Research Interests:

Current programmes are based in London, Philadelphia and China. They involve studies to promote the concept of type 1 diabetes as a broad clinical, genetic and immunological spectrum in which adult-onset autoimmune diabetes is prevalent. He is also extending the Epigenome Wide Association Studies in type 1 diabetes in collaboration with other BLUEPRINT colleagues.

Publications

Key Pubications

Ibrahim M, Baker J, Cahn A, Eckel RH, El Sayed NA, Fischl AH, Gaede P, Leslie RD, Pieralice S, Tuccinardi D, Pozzilli P, Richelsen B, Roitman E, Standl E, Toledano Y, Tuomilehto J, Weber SL, Umpierrez GE. Hypoglycaemia and its management in primary care setting. Diabetes Metab Res Rev. 2020 Apr 28:e3332

Cardona A, Day FR, Perry JRB, Loh M, Chu AY, Lehne B, Paul DS, Lotta LA, Stewart ID, Kerrison ND, Scott RA, Khaw KT, Forouhi NG, Langenberg C, Liu C, Mendelson MM, Levy D, Beck S, Leslie RD, Dupuis J, Meigs JB, Kooner JS, Pihlajamäki J, Vaag A, Perfilyev A, Ling C, Hivert MF, Chambers JC, Wareham NJ, Ong KK. Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study. Diabetes. 2019 Dec;68(12):2315-2326.

Leslie RD, Vartak T. Allostasis and the origins of adult-onset diabetes. Diabetologia. 2020 Feb;63(2):261-265.

Mishra R, Åkerlund M, Cousminer DL, Ahlqvist E, Bradfield JP, Chesi A, Hodge KM, Guy VC, Brillon DJ, Pratley RE, Rickels MR, Vella A, Ovalle F, Harris RI, Melander O, Varvel S, Hakonarson H, Froguel P, Lonsdale JT, Mauricio D, Schloot NC, Khunti K, Greenbaum CJ, Yderstræde KB, Tuomi T, Voight BF, Schwartz S, Boehm BO, Groop L, Leslie RD, Grant SFA. Genetic Discrimination between LADA and Childhood-Onset Type 1 diabetes within the MHC. Diabetes Care. 2020 Feb;43(2):418-425.  

Xiang Y, Huang G, Zhu Y, Zuo X, Liu X, Feng Q, Li X, Yang T, Lu J, Shan Z, Liu J, Tian H, Ji Q, Zhu D, Ge J, Lin L, Chen L, Guo X, Zhao Z, Li Q, Weng J, Jia W, Liu Z, Ji L, Yang W, Leslie RD, Zhou Z; China National Diabetes and Metabolic Disorders Study Group. Identification of autoimmune type 1 diabetes and multiple organ-specific autoantibodies in adult-onset non-insulin-requiring diabetes in China: A population-based multicentre nationwide survey. Diabetes Obes Metab. 2019 Apr;21(4):893-902


View all David Leslie's Research Publications at: http://www.researchpublications.qmul.ac.uk

Supervision

Dr Samuel Jerram