Blizard Institute - Barts and The London

Professor David Leslie, MB BS, MRCS, MD, FRCP


Professor of Diabetes and Autoimmunity

Telephone: 020 7882 2358


Professor David Leslie is consultant physician at St Bartholomew's Hospital and Professor of Diabetes and Autoimmunity at the Blizard Institute, Queen Mary, University of London. He was recently elected President of The Association of Physicians of Great Britian and Ireland.

He qualified and trained at Imperial College and subsequently at King's College Hospital and Royal Victoria Infirmary, Newcastle. He was an MRC Travelling Fellow at the University of Chicago, USA, and Welcome Trust Senior Clincal Research Fellow at both King's College and Charing Cross and Westminster Medical Schools.

He has an interest in the cause of autoimmune diabetes through the study of twins and disease syndromes.




Professsor David Leslie has been Professor of Diabetes and Autoimmunity at the Blizard Institute, University of London He has published 12 books and more than 200 peer-reviewed papers and received grants from many agencies including the EU, Wellcome Trust and MRC. In 2012 he was elected President of the Association of Physicians of Great Britain and Ireland. He ran the Diabetes Department at St Bartholomews Hospital, London with extensive experience of all aspects of diabetes, having previously been a consultant at Kings College Hospital. 


Teaches clinical and basic science to undergraduate students (PBL and SSC), visiting students and research fellows, Erasmus Students, BSc course (QMUL) MSc course (Kings), Central South University (China), University of Rome (Italy).


BSc Immune Diseases (QMUL)


Research Interests:

Professor Leslie has been Principle Investigator of three major EU programmes (EXALT, BLUEPRINT and Action LADA) and Founding Chairman of T1DUK. His research is based on the use of cutting-edge technology applied to unique cohorts (e.g. twins and adult onset autoimmune diabetes patients) to define the nature and origins of type 1 diabetes. These results led to work as Principle Investigator of three major EU programmes (EXALT, BLUEPRINT and Action LADA). He has been awarded lectures on several continents, e.g. Royal College of Physicians (London) Lecture, The Lily Lecture (Ireland), Niall O’Mara Lecture (Ireland), Silver Jubilee Oration (India), Xiangya Lecture (China). He held Visiting Chairs in USA (Chicago and Kansas) and Europe (Rome) and is an Emeritus Professor in China (Central South University). He was Senior Examiner Chinese University Hong Kong in 2013 and am currently am the founding Chairman of T1DUK, a UK consortium of leading UK researchers set up to investigate and prevent type 1 diabetes. Notable awards include: a Medical Research Council Travelling Fellowship to USA, the Royal College of London Leonard Simpson Fellowship and Wellcome Trust Senior Fellowship in Clinical Science. He was co-author of an award-winning textbook (BMA Book of the Year Award 2009), Director of the Mendel Institute, Rome, Italy, Co-Editor of Diabetes Metab. Res. Rev., Reviews Editor of Diabetic Medicine and served on the Editorial Board of Diabetes Care.


Key Publications

Mishra R, Chesi A, Cousminer DL, Hawa MI, Bradfield JP, Hodge KM, Guy VC, Hakonarson H; Bone Mineral Density in Childhood Study., Mauricio D, Schloot NC, Yderstræde KB, Voight BF, Schwartz S, Boehm BO, Leslie RD*, Grant SFA*. *(co-corresponding and senior authors)

Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes. BMC Med. (2017) Apr 25;15(1):88.

Paul DS, Teschendorff AE, Dang MA, Lowe R, Hawa MI, Ecker S, Beyan H, Cunningham S, Fouts AR, Ramelius A, Burden F, Farrow S, Rowlston S, Rehnstrom K, Frontini M, Downes K, Busche S, Cheung WA, Ge B, Simon MM, Bujold D, Kwan T, Bourque G, Datta A, Lowy E, Clarke L, Flicek P, Libertini E, Heath S, Gut M, Gut IG, Ouwehand WH, Pastinen T, Soranzo N, Hofer SE, Karges B, Meissner T, Boehm BO, Cilio C, Elding Larsson H, Lernmark Å, Steck AK, Rakyan VK, Beck S, Leslie RD.

Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.

Nat Commun. (2016); 7:13555. doi: 10.1038/ncomms13555

Stunnenberg HG; International Human Epigenome Consortium, Hirst M.: A Blueprint for Scientific Collaboration and Discovery. Cell. (2016);167(5):1145-1149. doi: 10.1016/j.cell.2016.11.007.

View all David Leslie's Research Publications at: