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John Connelly, Ph.D.

John

Reader

Email: j.connelly@qmul.ac.uk
Telephone: +44 (0)207 882 7160

Profile

I received my B.S. in Biological and Environmental Engineering from Cornell University and my Ph.D. in Bioengineering from the Georgia Institute of Technology where I investigated the chondrogenesis of mesenchymal progenitors within engineered hydrogels.  I then did my postdoctoral training in Professor Fiona Watt’s laboratory at the University of Cambridge where I developed micro-patterned substrates to study the roles of cell shape and the actin cytoskeleton in keratinocyte terminal differentiation. I joined Queen Mary University of London in 2010 and lead an interdisciplinary research group in skin biomechanics and mechano-sensing.

Summary

My laboratory is interested in how keratinocytes sense and respond to changes in their physical microenvironment. We employ engineered materials and model systems to precisely control the signals presented to cells.
Key projects include:
(1) The role of biophysical cues in epidermal fate decisions.
(2) The influence of substrate mechanics and topography on wound healing.
(3) Transcriptional regulators of mechano-transduction in keratinocytes.
We also have an on-going interest in tissue engineering and regenerative medicine, and a long-term goal for our research is to translate our findings into effective strategies for skin repair.

Teaching

Course director MSc Regenerative Medicine

Module Lead ICM7143: Biomaterials in Regenerative Medicine

Module Lead ICMM132: Research Skills and Methodology

Problem Based Learning


Research

Research Interests:

My laboratory is interested in how keratinocytes sense and respond to changes in their physical microenvironment.  We employ engineered materials and model systems to precisely control the signals presented to cells.  Key projects include: (1) The role of biophysical cues in epidermal fate decisions.  (2) The influence of substrate mechanics and topography on wound healing. (3) Transcriptional regulators of mechano-transduction in keratinocytes.  We also have an on-going interest in tissue engineering and regenerative medicine, and a long-term goal for our research is to translate our findings into effective strategies for skin repair.

Publications

Sharili AS, Kenny FN, Vartiainen MK, Connelly JT. “Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes” Scientific Reports, 2016; 6:33893.

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM, Connelly JT. “Type VI collagen regulates dermal matrix assembly and fibroblast motility” Journal of Investigative Dermatology, 2016; 136(1): 74-83.

Almeida FV, Walko G, McMillan JR, McGrath JA, Wiche G, Barber AH, Connelly JT. “The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes” Journal of Cell Science. 2015; 128(24): 4475-86.

Costa P, Gautrot JE, Connelly JT. “Directing cell migration using micro-patterned and dynamically adhesive polymer brushes” Acta Biomaterialia, 2014; 10(6): 2415-22.

Connelly JT, Gautrot JE, Trappmann B, Tan DW, Huck WTS, Watt FM.  “Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions” Nature Cell Biology, 2010; 12(7):711-8.


View all John Connelly's Research Publications at: http://www.researchpublications.qmul.ac.uk

PhD Supervision

Research Group Members

Dr. Liisa Blowes

Miss Ana Laly Aguedo

Mr Oscar Pundel

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