The Women’s Health Research Unitundertakes multidisciplinary research to understand why a woman and her unborn child can become ill and how they can stay healthy.
The unit conducts clinical trials and systematic reviews collaboratively with patient and public involvement. Input from a range of disciplines such as clinical epidemiology, biostatistics and health technology assessment are the cornerstones of research that improve policy and practice, embedded within communities and health systems locally, nationally and globally.
Probiotics in the prevention of preterm birth - pilot randomised trial
This is a Barts Charity funded feasibility trial to determine the biological effects of probiotics on the vaginal flora and examine the components that will be essential to the success of a double-blinded, placebo-controlled randomised trail (RCT) on the effects of oral probiotics administered daily from early pregnancy on the risk of pre-term birth.
GBS2 is a cluster randomised trial designed to investigate the real time accuracy of a rapid PCR test to detect GBS colonisation among women in labour with risk factors. GBS2 will also evaluate if using this rapid intrapartum test for GBS colonisation reduces maternal and neonatal antibiotic usage compared with the usual care of Intrapartum Antibiotic Prophylaxis (IAP) based on maternal risk factors alone. We aim to recruit a minimum of 8 clusters per arm (total 16 hospitals), from which we estimate 84 women with risk factors will be recruited.
GIFTS - Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples
SALVO- A randomised controlled trial of intra-operative cell salvage during caesarean section in women at risk of haemorrhage
ESTEEM: Effect of simple, targeted diet in pregnant women with metabolic risk factors on pre-eclampsia. A randomised trial.
IPPIC: Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of pre-eclampsia: an Individual Patient Data (IPD) Meta-analysis
Ongoing research with other institutions (Subcontracted to QM)
HABselect (Leeds) - Selection of sperm for Assisted Reproductive Treatment by prior hyaluronic acid binding: increasing live birth outcomes and reducing miscarriage rates (Hyaluronic Acid Binding Sperm Selection; HABSelect).
TABLET (Birmingham) - Efficacy and mechanism of thyroxine treatment on pregnancy and neonatal outcomes in women with thyroid antibodies: A randomised, placebo-controlled, double-blind, multi-centre trial [The TABLET (Thyroid AntiBodies and LEvoThyroxine) Trial]
EMPiRE- Antiepileptic drug (AED) management in Pregnancy: An evaluation of effectiveness, cost effectiveness and acceptability of dose adjustment strategies
MEDAL- Can magnetic resonance imagining (MRI) scan replace or triage the use of laparoscopy in establishing a diagnosis among women presenting in secondary care with chronic pelvic pain (CPP)?
PREP - Development and validation of a prediction model for risk of complications in early onset pre-eclampsia
iWIP IPD M-A - Effects of weight management interventions on maternal and fetal outcomes in pregnancy: Individual patient data (IPD) meta-analysis of randomised trials and model based economic evaluation
EBM Connect - Evidence-based Medicine Collaboration Network for guideline development, teaChing and disseminaTion
Cervical Cancer (PET CT) - Clinical effectiveness of PET-CT imaging in restaging recurrent cervical cancer: Systematic review of evidence and economic modelling
Obesity in Pregnancy - Interventions to reduce or prevent obesity in pregnant women: A systematic review of evidence synthesis (Obesity in pregnancy)
Vulval Cancer (Sentinel Node) - Sentinel lymph node (SLN) status in vulval cancer: Systematic quantitative reviews and decision analytic model based economic evaluation
Previous studies with other institutions (Subcontracted to QM):
BUS (Birmingham) - Accuracy of Bladder Ultrasound (BUS) in the diagnosis of Detrusor Overactivity: a study to evaluate if ultrasound can reduce the need for urodynamics
PLUTO (Birmingham) - Percutaneous Shunting in Bladder Outlet Obstruction Trial
STAMP (Edinburgh) - (A Proof of Principle, Double-Blind, Randomised Placebo-Controlled, Multi-Centre Trial of pravaStatin to Ameliorate Early Onset Pre-eclampsia)
DAPPA - How accurate is spot urinary protein: creatinine ratio (SPCr) and spot albumin:creatinine ratio (SACr) compared to 24-hour protein estimation to assess women with hypertensive disease in pregnancy (HDP) after 24 weeks gestation
Katie’s Team – The women’s health research patient and public advisory group for East London.
“Katie’s Team” is the
KT Network patient and public advisory group. It consists of mums and local members of the public who have a connection to our research areas of childbirth, pregnancy and reproductive issues.
What do we do?
We meet face to face 3 times a year to comment on specific research questions, to advise on the direction of the research, and to learn more about how research in women’s health is conducted. For example, Katie’s Team members have advised on how to reach women who had diabetes in pregnancy for follow-up studies; or given their opinion on what the relevant outcomes were for pregnant women who were anaemic; or commented on learning materials that are used to spread the word about research.
Why do it?
The purpose of the group is to ensure that women’s health research is done effectively and remains relevant to the needs of local mothers. That’s because women who have experienced pregnancy and childbirth issues have unique insight that is valuable to the researchers. “Katie’s Team” members also act as champions for research within their own communities.
Who can join?
Anyone with a personal experience of childbirth, pregnancy or reproductive issues, and their partners or family members. We particularly welcome members from East London. If you live outside of London, you are welcome to join our mailing list – we also send out electronic newsletters every few months with updates and involvement opportunities.
Get in touch on email@example.com, and we can send you a role description and further information.
Professor Khalid Khan - Professor of Women's Health and Clinical Epidemiology 0207 882 2621 / 07977 559 415
The Katherine Twining Network aims to facilitate multidisciplinary research in reproductive health and childbirth, providing leadership in development and delivery of women’s health studies. It is named after the first Matron and founder of the Plaistow Maternity Hospital (established in 1889 as St Mary's District Nurses' Home). Its services are currently delivered through the maternity provision at Newham General Hospital.
This initiative aims to bring together doctors, nurses, midwives and scientists working towards improvement in women's health in East London and beyond.
Katherine Twining Network supports and actively encourages the involvement in trainees in research. This includes the provision of academic training, supervision of MD and PhD students, and involvement of clinical trainees in ongoing research activities. We support the establishment of a trainee-led network that improves research literacy and trainee participation in research. This will be provided through our online website where trainees can complete EBM e-learning packages, access databases with research opportunities and learn about how to organise out of programme placements. Along with online resources, it will provide a network for those trainees already involved in research or interested in exploring the world of academic medicine.