Lead: Professor Silvia Marino
We are a multidisciplinary research group composed of basic scientists and clinical researchers with the common aim to apply knowledge of basic stem cell biology to advance our understanding of human disease.
We study epigenetic mechanisms regulating the biology of normal and neoplastic stem cells. We are investigating the role of deregulated self-renewal mechanisms in initiation and progression of brain tumours. Moreover, we are interested in assessing how fine tuning of the expression of chromatin modifiers, such as the PcG genes, can be exploited to enhance the regenerative function of stem cells in developmental and adult diseases..
Professor Marino leads a research programme in the epigenetic regulation of stem cell function during CNS development and brain tumour formation. In particular, she is investigating the role of deregulated self-renewal mechanisms in initiation and progression of brain tumours.
In the context of the Brain Tumour Research Centre of Excellence, the group focuses on glioblastoma multiforme (GBM), the most common and most aggressive malignant brain tumour of adulhood. The aim of the research is to increase our understanding of the cells within the brain from which GBM originates. The team will look at how this particular type of brain tumour develops from normal cells, and which genes and biological functions control its behaviour. By uncovering this essential knowledge, the clinical evaluation of each individual patient can be improved and better and more specific drugs which target the tumour cells can be identified.
In MRC-funded studies, the Marino group is studying the role of chromatin regulation, particularly through the Polycomb group (PcG) genes, in the development of medulloblastoma, the most common malignant brain tumour in children.
Finally, Prof Marino is interested in assessing how fine tuning of the expression of chromatin modifiers, such as the PcG genes, can be exploited to enhance the regenerative function of stem cells in developmental and adult diseases.
Current projects in the lab are funded by Brain Tumour Research, MRC, Barts and The London Charity and NIHR.
Prof Marino is the academic lead for the NIHR Integrated Academic Training at QMUL
Prof Marino is pleased to consider applications from prospective PhD students.
Prof Marino is pleased to consider applications for prospective lab placements.
Prof Silvia Marino (Group Lead)
Dr Maria Niklison-Chirou (Children with Cancer UK Fellow)
Post-Doctoral Researchers and Fellows
Dr Claire Vinel, Dr Gabriel Rosser, Dr Loredana Guglielmi, Dr Sara Badodi, Dr Veronica Freire Beneitez
Clinical Research Fellows
Dr Ashirward Merve, Dr Peter Hall, Dr Thomas Millner
Ms Anaelle Dumas, Ms Barbara Ricci, Mr James Boot
Dr Xinyu Zhang
Ms Jayanthi Rajamanje (centre administrator)
Ms Nancy Schumann (NIHR IAT Programme administrator)
Prof. Silvia Marino
email@example.com Tel: +44 (0)20 7882 2585 Fax: +44 (0)20 7882 2180
Dr Xinyu Zhang
firstname.lastname@example.org Tel: +44 (0)20 7882 2201 Fax: +44 (0)20 7882 2180
Ms Nancy Schumann
email@example.com Tel. +44 (0)20 7882 3365
Centre for Genomics and Child Health
Barts and The London School of Medicine and Dentistry
4 Newark Street, London E1 2AT
Tel: +44 (0)20 7882 2483