Blizard Institute - Barts and The London

Barts Diabetes & Obesity Research Group

Diabetes Studies

The Diabetes Research Group has a broad portfolio of studies. We undertake both clinical trials and questionnaire/qualitative research. Our current portfolio is listed below:

ADDRESS-2 for People with Type 1 Diabetes

To establish a resource to facilitate enrolment into future type 1 diabetes studies through collection of data and blood samples from people with type 1 diabetes within 6 months of diagnosis.

For further information, please contact: Victoria Berryman, Research Nurse, on 02078822592 or email victoria.berryman@bartshealth.nhs.uk or Melanie Pattrick, Senior Research Nurse, melanie.pattrick@bartshealth.nhs.uk.

My Diabetes Study for People with Type 1 & 2 Diabetes

To explore and describe the different types of diabetes that exist in people diagnosed at a young age (under 30 years of age) in the UK, with a focus on differences between ethnic groups.
For further information, please contact: Anne Worthington, Research Study Coordinator: on 020 7882 8806 or email anne.worthington@bartshealth.nhs.uk.

NAFLD (Non-Alcoholic Fatty Liver Disease in People with Type 2 Diabetes

To identify ways of quickly and conveniently identifying patients at risk of liver disease, so that treatment can be targeted at those who need it before the development of serious complications.
For further information, please contact: Johanna Preston, Research Study Co-ordinator, on 020 7882 2592 or email johanna.preston@bartshealth.nhs.uk 

The Diabetes Essentials Care Survey - CI/PI – Dr Gillian Hood

This is an anonymous, questionnaire-based study.  The aims are to identify areas of diabetes primary health care that are going well or need improving, improve the knowledge of participants and help support patients in the self-management of their condition.  This study will be running until the 30th November 2019, with a target recruitment figure of 14000, in both NE and NW London Sites and the Home Counties.

The TOGETHER Study (Better care for young adults with diabetes using group clinics) – CI/PI Dr Sarah Finer

The research team are involved in new ways of delivering better care to young adults living with diabetes, as medical care in hospital clinics with 1-to-1 appointments may not always meet their needs.  Recent research has suggested that ‘group’ clinics may be a better way to support young people with long-term health problems, and may be a better way to meet their needs.  The diabetes research team at Mile End and Whitechapel are working with people who receive usual care (1-to-1 appointments).  The team at Newham are working with participants in group clinics, and group clinics.  The study will be running until the 30th November 2019.  Participants receiving usual care will be seen by a researcher at the beginning of the study and then one year later.

EXALT study, Phase I study of IMCY-0098 in Recent Onset Type 1 Diabetes – PI: Professor David Leslie

As part of the Type 1 Diabetes UK Immunotherapy Consortium, we have the exciting opportunity to be one of 6 sites here in the UK recruiting to the EXALT study. This study is investigating a new “therapeutic vaccine” designed to stop the immune system from attacking cells that produce insulin, which may help preserve insulin production in people with recently diagnosed type 1 diabetes. The main purpose of this study is to assess the safety of three different doses of this new investigational treatment in people who have been recently diagnosed with type 1 diabetes. For this study we are looking for people 18-30 years of age, who have been diagnosed with type 1 diabetes in the last 6 months. Participation will last approximately 24 weeks.
For further information, please contact: Melanie Pattrick, on 020 7882 8610 or email melanie.pattrick@bartshealth.nhs.uk 

Major research grants:

  1. GIFTS: Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples. EU FP7, 3 million Euros, 2012-6. http://www.gifts-project.eu. Co-ordinator Hitman
  2. BLUEPRINT Project: Epigenetics of Type 1 Diabetes in Identical Twins EU FP7. WP leader Leslie
  3. COMBAT Type 1: To examine the effect of blockade of immunological co-stimulation on auto-reactive T cells in type 1 diabetes. PI Leslie
  4. TOGETHER study: Can group clinics deliver better care to young adults with diabetes? NIHR HS+DR 15/25/20, £382,000, 2016-2019 CI Finer https://www.journalslibrary.nihr.ac.uk/projects/152520/#/
  5. Patient Managed Decision-Support using Bayesian Networks (PAMBAYESIAN). EPSRC grant, PI Norman Fenton CoPIs: Marsh, Morrissey, Neil, Curzon, Alomainy, Hitman, Patel, Humby, Collier, Huda, Brown. EPSRC £1,539,497 May 2017-April 2020 Grant number EP/P009964/1 
  6. Identification of barriers to effective diabetes management for people with severe mental illness (SMI): Development work for an intervention to improve diabetes healthcare and self-care in SMI. Mulligan K, McBain H, Simpson A, Priebe S, Haddad M, Hitman GA, Hull S, Hilton N,Jones J, Flood C Newman S. Bart and The London Charity. Grant Reference Number: 477/2314 £33,594.00 2015-2016
  7. Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT)? HTA NIHR. Giffin S, Wareham N, Simmons R, Sharp S, Davies M, Khunti K, Hitman GA, Rutter M, Holman R, Greaves C, Millward A, Evans P, Sattar N, Petrie J, Gray A. £625,008 for pilot. QMUL does not get any money from the pilot; end date Dec 2016
  8. Prevention of Diabetes Complications in people with Hyperglycaemia in Europe; FP7-HEALTH-2011-two-stage. Co-ordinating person J Tuomilehto. GAH contribution is genetics £98,000 2012-31st Dec 2017
  9. Non Alcoholic Fatty Liver Disease – Diabetes Research and Wellness Foundation – Dr Will Alazawi
  10. Diabetes and Kidney Disease. Prof Magdi Yaqoob Barts and The London Charity £4million
  11. Action on sugar Prof Graham Macregor, http://www.actiononsugar.org/146034.html

MBBS Undergraduate curriculum: core lectures, problem-based learning, clinical teaching

 

 

MSc Diabetes and Endocrinology

 

BSc Global Health

 

MSc Global Public Health and Policy

 

 

Core academic team

Professor of Molecular Medicine and Diabetes
 
Professor of Diabetes and Autoimmunity / Centre Lead, Centre for Immunobiology.
 
Professor of Diabetes and Clinical Research.
 
Clinical Senior Lecturer in Diabetes. Women’s Health Research Unit
 
Lecturer in Genomics. Centre for Genomics and Child Health
 
Reader in Metabolic Medicine. Centre for Cell Biology and Cutaneous Research
 
Prof Barbara Boucher
Emeritus Professor of Diabetes

Research support and delivery team

Dr Gill Hood
Diabetes Research Manager

Ms Melanie Pattrick
Senior Diabetes Research Nurse

Miss Johanna Preston
Diabetes Research Coordinator

Ms Victoria Berryman
Diabetes Research Nurse

Ms Anne Worthington
Diabetes Research Coordinator

 

Clinical Research fellows

Dr Sam Jerram
Clinical Research Fellow, Diabetes and Immunobiology
Supervisor: Prof David Leslie, Centre for Immunobiology, Blizard Institute, QMUL

Dr Niki Margari
Clinical Research Fellow in Diabetes
Supervisor: Dr Sarah Finer. Women’s Health Research Unit, Blizard Institute, QMUL

Dr Meera Ladwa
Clinical Research Fellow in Diabetes
Supervisor: Dr Sarah Finer. Women’s Health Research Unit, Blizard Institute, QMUL

Dr Donata Iacovacco
Diabetes UK Clinical Training Fellow
Supervisor: Prof Marta Korbonits. Centre for Endocrinology, William Harvey Institute

 

Other QMUL academic investigators

Centre for Genomics and Child Health, Blizard Institute, QMUL
 
Institute of Dentistry, QMUL
 
Centre for Immunobiology, Blizard Institute, QMUL
 
Women’s Health Research Unit, Centre for Primary Care and Public Health, Blizard Institute, QMUL
 
School of Electronic Engineering and Computer Science, QMUL
 
School of Electronic Engineering and Computer Science, QMUL
 
Dr John Robson
Clinical Effectiveness Group. Centre for Primary Care and Public Health, Blizard Institute, QMUL
 
Centre for Genomics and Child Health, Blizard Institute, QMUL
 
Centre for Endocrinology, William Harvey Institute, QMUL
 
Experimental Medicine & Pharmacology, William Harvey Institute
Professor of Cardiovascular Medicine. Wollfson Institute of Preventative Medicine, QMUL

 

Key clinical colleagues

Dr Karl Metcalfe
Consultant in Diabetes and Endocrinology. Barts Health Diabetes Network Lead. Barts Health NHS Trust
 
Consultant in Diabetes. Bart’s Health NHS Trust
 
Anne Claydon
Nurse Consultant in Diabetes. Barts Health NHS Trust
 
Consultant in Diabetes and Endocrinology. Barts Health NHS Trust
 
Consultant in Diabetes and Metabolic Medicine. Bart’s Health NHS Trust
 
Consultant in Diabetes and Endocrinology. Barts Health NHS Trust

 

Consortia

Type 2 Diabetes Collaborative Group (T2DCG)
Genomic Investigation of Statin Therapy (GIST)
Type 1 Diabetes UK Consortium (T1DUK)
Blueprint
GIFTS
General
QMUL Innovations, Room G2
5 Walden St,
Whitechapel, E1 2EF
Tel.: 02078823916
Email: diabetesresearch@bartshealth.nhs.uk
 
Clinical studies recruitment
Melanie Pattrick 
Senior Research Nurse
Tel.: 02078823916
Email: melanie.pattrick@bartshealth.nhs.uk