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Blizard Institute - Faculty of Medicine and Dentistry

Blizard Institute's Prof David Kelsell awarded £1.1 million Cancer Research UK programme grant

Blizard Institute's Professor David Kelsell and colleagues including Professor Andy Silver have been awarded a £1.1million Cancer Research UK (CRUK) programme grant to work on squamous oesophageal cancer.


The Kelsell group discovered the first major gene (iRHOM2) that causes an inherited form of oesophageal cancer called Tylosis and then developed functional data as to how mutant  iRHOM2 may lead to this devastating cancer. Oesophageal cancer is a leading cause of cancer related deaths worldwide with a very limited survival rate after five years – yet it remains a largely under-studied cancer.

The grant award will allow the team to study a number of aspects related to iRHOM2 and cellular pathways regulated by this molecule including investigating biopsy material from patients who are at risk of this cancer due to the mutation they have inherited in iRHOM2.

Previous support on this work has come from Barts Charity which allowed the mechanistic data to be generated to facilitate this prestigious programme grant from CRUK.



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