Andy Prendergast from the Centre for Genomics and Child Health has been awarded a five-year Wellcome Trust Senior Clinical Fellowship to continue work he is undertaking in Zimbabwe on malnutrition. His group is exploring interventions to prevent stunting in childhood - an often overlooked form of chronic malnutrition which increases mortality from infections and impairs long-term child development. His current work on the SHINE trial is evalauting the independent and combined effects of improving water/hygiene/sanitation or infant feeding on stunting. In his Senior Fellowship, Andy has been awarded £2M from the Wellcome Trust to undertake a trial to evaluate the impact of the antibiotic cotrimoxazole on birth outcomes and growth in rural Zimbabwe. Antenatal women will be randomized to cotrimoxazole or placebo to see whether antibiotics reduces prematurity and increase birth weight, then infants will be randomized to cotrimoxazole or placebo to evaluate the impact of antibiotics on linear growth by 6 months. Specimens will be collected from mothers and infants to explore the impact of antibiotics on inflammation, immune function, intestinal inflammation and the microbiota, in laboratory work to be undertaken in Zimbabwe and at the Blizard Institute.
29 July 2015