New enzymes (February 2004, approved April 2004)An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (May 2004, approved June 2004)
New enzymes (September 2004, approved November 2004) Minor changes
*EC 1.1.1.24 quinate dehydrogenase
*EC 1.1.1.25 shikimate dehydrogenase
*EC 1.1.1.87 homoisocitrate dehydrogenase
EC 1.1.1.155 identical to EC 1.1.1.87
EC 1.1.1.204 now EC 1.17.1.4
EC 1.1.1.281 GDP-4-dehydro-6-deoxy-D-mannose reductase
EC 1.1.1.282 quinate/shikimate dehydrogenase
EC 1.1.3.22 now EC 1.17.3.2
*EC 1.1.99.25 quinate dehydrogenase (pyrroloquinoline-quinone)
EC 1.1.99.29 pyranose dehydrogenase (acceptor)
EC 1.1.99.30 2-oxoacid reductase
EC 1.2.1.70 glutamyl-tRNA reductase
*EC 1.2.3.1 aldehyde oxidase
*EC 1.2.3.7 indole-3-acetaldehyde oxidase
EC 1.2.99.7 aldehyde dehydrogenase (FAD-independent)
*EC 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
*EC 1.3.1.54 precorrin-6A reductase
EC 1.3.1.55 now EC 1.3.1.25
*EC 1.3.1.51 2'-hydroxydaidzein reductase
EC 1.3.1.76 precorrin-2 dehydrogenase
EC 1.3.1.77 anthocyanidin reductase
EC 1.3.99.22 coproporphyrinogen dehydrogenase
EC 1.5.1.13 now EC 1.17.1.5
*EC 1.5.1.27 1,2-dehydroreticulinium reductase (NADPH)
*EC 1.5.99.9 methylenetetrahydromethanopterin dehydrogenase
*EC 1.5.99.11 5,10-methylenetetrahydromethanopterin reductase
*EC 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
EC 1.8.5.2 thiosulfate dehydrogenase (quinone)
EC 1.11.1.15 peroxiredoxin
*EC 1.12.98.2 5,10-methenyltetrahydromethanopterin hydrogenase
*EC 1.13.12.5 Renilla-luciferin 2-monooxygenase
EC 1.13.12.13 Oplophorus-luciferin 2-monooxygenase
*EC 1.14.11.9 flavanone 3-dioxygenase
EC 1.14.11.22 flavone synthase
EC 1.14.11.23 flavonol synthase
*EC 1.14.13.22 cyclohexanone monooxygenase
EC 1.14.13.83 precorrin-3B synthase
EC 1.14.13.84 4-hydroxyacetophenone monooxygenase
EC 1.14.13.85 glyceollin synthase
EC 1.14.13.86 2-hydroxyisoflavanone synthase
EC 1.14.13.87 licodione synthase
EC 1.14.13.88 flavonoid 3',5'-hydroxylase
EC 1.16.8 With flavin as acceptor
EC 1.16.8.1 cob(II)yrinic acid a,c-diamide reductase
*EC 1.17 Acting on CH or CH2
EC 1.17.1.4 xanthine dehydrogenase
EC 1.17.1.5 nicotinate dehydrogenase
EC 1.17.3.2 xanthine oxidase
EC 1.17.3.3 6-hydroxynicotinate dehydrogenase
EC 1.17.5 With a quinone or similar compound as acceptor
EC 1.17.5.1 phenylacetyl-CoA dehydrogenase
*EC 1.97.1.4 [formate-C-acetyltransferase]-activating enzyme
*EC 2.1.1.107 uroporphyrin-III C-methyltransferase
EC 2.1.1.151 cobalt-factor II C20-methyltransferase
EC 2.1.1.152 precorrin-6A synthase (deacetylating)
EC 2.1.1.153 vitexin 2"-O-rhamnoside 7-O-methyltransferase
EC 2.1.1.154 isoliquiritigenin 2'-O-methyltransferase
EC 2.1.1.155 kaempferol 4'-O-methyltransferase
EC 2.3.1.170 6'-deoxychalcone synthase
EC 2.3.1.171 anthocyanin 6"-O-malonyltransferase
EC 2.3.1.172 anthocyanin 5-O-glucoside 6'''-O-malonyltransferase
EC 2.3.1.173 flavonol-3-O-triglucoside O-coumaroyltransferase
EC 2.4.1.93 now EC 4.2.2.18
*EC 2.4.1.99 sucrose:sucrose fructosyltransferase
*EC 2.4.1.100 2,1-fructan:2,1-fructan 1-fructosyltransferase
EC 2.4.1.200 now EC 4.2.2.17
EC 2.4.1.232 glycolipid 6-α-mannosyltransferase
EC 2.4.1.233 anthocyanidin 3-O-glucosyltransferase
EC 2.4.1.234 kaempferol 3-O-galactosyltransferase
EC 2.4.1.235 cyanidin 3-O-rutinoside 5-O-glucosyltransferase
EC 2.4.1.236 flavanone 7-O-glucoside 2"-O-β-L-rhamnosyltransferase
EC 2.4.1.237 flavonol 7-O-β-glucosyltransferase
EC 2.4.1.238 anthocyanin 3'-O-β-glucosyltransferase
EC 2.4.1.239 flavonol-3-O-glucoside glucosyltransferase
EC 2.4.1.240 flavonol-3-O-glycoside glucosyltransferase
*EC 2.4.99.7 (α-N-acetylneuraminyl-2,3-β-galactosyl-1,3)-N-acetyl-galactosaminide 6-α-sialyltransferase
*EC 2.5.1.17 cob(I)yrinic acid a,c-diamide adenosyltransferase
EC 2.5.1.37 now EC 4.4.1.20
EC 2.5.1.65 O-phosphoserine sulfhydrylase
EC 2.5.1.66 N2-(2-carboxyethyl)arginine synthase
*EC 2.6.1.11 acetylornithine transaminase
*EC 2.6.1.22 (S)-3-amino-2-methylpropionate transaminase
*EC 2.6.1.40 (R)-3-amino-2-methylpropionate—pyruvate transaminase
EC 2.6.1.61 identical to EC 2.6.1.40
EC 2.6.1.69 now EC 2.6.1.11
*EC 2.7.1.52 fucokinase
EC 2.7.1.70 identical to EC 2.7.1.37.
EC 2.7.1.156 adenosylcobinamide kinase
*EC 2.7.7.28 nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase
EC 2.7.7.29 identical to EC 2.7.7.28
EC 2.7.7.62 adenosylcobinamide-phosphate guanylyltransferase
EC 2.7.8.26 adenosylcobinamide-GDP ribazoletransferase
EC 2.8.2.31 petromyzonol sulfotransferase
EC 3.1.1.79 hormone-sensitive lipase
EC 3.1.2.25 phenylacetyl-CoA hydrolase
*EC 3.1.3.25 inositol-phosphate phosphatase
EC 3.1.3.73 α-ribazole phosphatase
EC 3.1.3.74 pyridoxal phosphatase
EC 3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
*EC 3.2.1.64 2,6-β-fructan 6-levanbiohydrolase
*EC 3.2.1.132 chitosanase
EC 3.2.1.148 now EC 3.13.1.2
*EC 3.2.2.5 NAD+ nucleosidase
*EC 3.2.2.9 adenosylhomocysteine nucleosidase
*EC 3.2.2.16 methylthioadenosine nucleosidase
*EC 3.2.2.19 ADP-ribosylarginine hydrolase
*EC 3.3.1 Thioether and trialkylsulfonium hydrolases
*EC 3.3.1.1 adenosylhomocysteinase
EC 3.5.1.90 adenosylcobinamide hydrolase
EC 3.5.2.17 hydroxyisourate hydrolase
EC 3.13.1.2 5-deoxyribos-5-ylhomocysteinase
EC 4.1.1.81 threonine-phosphate decarboxylase
*EC 4.2.1.27 acetylenecarboxylate hydratase
EC 4.2.1.29 now EC 4.99.1.6
*EC 4.2.1.47 GDP-mannose 4,6-dehydratase
EC 4.2.1.71 identical to EC 4.2.1.27
EC 4.2.1.86 deleted identical to EC 4.2.1.98
*EC 4.2.1.98 16α-hydroxyprogesterone dehydratase
EC 4.2.1.105 2-hydroxyisoflavanone dehydratase
EC 4.4.1.21 S-ribosylhomocysteine lyase
EC 4.2.2.16 levan fructotransferase (DFA-IV-forming)
EC 4.2.2.17 inulin fructotransferase (DFA-I-forming)
EC 4.2.2.18 inulin fructotransferase (DFA-III-forming)
EC 4.2.3.21 vetispiradiene synthase
*EC 4.3.1.9 glucosaminate ammonia-lyase
EC 4.3.1.21 identical to EC 4.3.1.9
EC 4.4.1.20 leukotriene-C4 synthase
EC 4.99.1.3 sirohydrochlorin cobaltochelatase
EC 4.99.1.4 sirohydrochlorin ferrochelatase
EC 4.99.1.5 aliphatic aldoxime dehydratase
EC 4.99.1.6 indoleacetaldoxime dehydratase
EC 5.3.3.13 polyenoic fatty acid isomerase
EC 6.3.1.10 adenosylcobinamide-phosphate synthase
EC 6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
EC 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)
EC 6.6.1.2 cobaltochelatase