Reaction: 3-sulfopyruvate = 2-sulfoacetaldehyde + CO2
For diagram of reaction click here
Glossary: thiamine diphosphate = 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium
2-sulfoacetaldehyde = 2-oxoethanesulfonate
Other name(s): 3-sulfopyruvate carboxy-lyase
Systematic name: sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)
Comments: Requires thiamine diphosphate. Does not decarboxylate pyruvate or phosphonopyruvate. The enzyme appears to be oxygen-sensitive.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 303155-97-7
References:
1. Graupner, M., Xu, H. and White, R.H. Identification of the gene encoding sulfopyruvate decarboxylase, an enzyme involved in biosynthesis of coenzyme M. J. Bacteriol. 182 (2000) 4862-4867. [PMID: 10940029]