Reaction: (2E)-3-methyl-5-phosphooxypent-2-enoate = 3-methylbut-3-en-1-yl phosphate + CO2
Glossary: (2E)-3-methyl-5-phosphooxypent-2-enoate = trans-anhydromevalonate 5-phosphate
3-methylbut-3-en-1-yl phosphate = isopentenyl phosphate
Systematic name: trans-anhydromevalonate 5-phosphate carboxy-lyase
Comments: The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Hayakawa, H., Motoyama, K., Sobue, F., Ito, T., Kawaide, H., Yoshimura, T. and Hemmi, H. Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate. Proc. Natl. Acad. Sci. USA 115 (2018) 10034–10039. [PMID: 30224495]
2. Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86 (2020) e02889-19. [PMID: 31924615]