Projects funded for this call involve collaborative work between the Blizard Institute / School of Medicine and Dentistry and the School of Engineering and Materials Science / Institute of Bioengineering; School of Medicine and Dentistry / William Harvey Research Institute / Clinical Pharmacology; Barts Cancer Institute / School of Medicine and Dentistry, and the School of Biological and Chemical Sciences; and the Blizard Institute / School of Medicine and Dentistry and the School of History / Faculty of Humanities and Social Sciences.
Topics include looking at the role played by genetic variants in the risk of coronary artery disease, investigating the interaction between the activation of senescence (a cellular response to damage) and the immune response in both cancer and ageing, and modelling the field cancerisation and its microenvironment in breast cancer.
- Characterisation of allele-specific variation and long-range interactions at the VEGFA locus
- Role for the cross-talk between macrophages and fibroblasts in senescence using 3D hydrogel culture systems
- An integrated multi-omics approach to model the field cancerisation and its microenvironment in breast cancer
- Medicines as emotional objects: multimorbidity and polypharmacy in socio-historical perspective