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Experimental Haematology (ICM6025)

Dept. responsible. Pathology Unit, Blizard Institute

Course organisers:

Prof Adrian Newland, a.c.newland@qmul.ac.uk

Dr Paul Allen, p.d.allen@qmul.ac.uk

Haematology is one of the cornerstones of pathology and will develop into a key component of our course. The module design aims to instil in-depth knowledge of blood diseases, how these diseases may be resolved and the latest in scientific and clinical developments in the field.

Topics include: Subject matter will include normal haemopoiesis, the achievement of haemostasis and the diseases associated with de-regulated haemostasis. The student will go on to acquire an associated knowledge of haemorrhagic and thrombotic disorders. Key elements of red cell abnormalities including the thalassaemias, sickle cell disease and certain anaemias e.g. Diamond Blackfan, are covered in-depth. The science and clinical aspects of blood transfusion will be covered. The module will encompass inherited bone marrow failures illustrated by lectures on monogenic disorders associated with aplastic anaemia such as Fanconi anaemia and dyskeratosis congenita. Progress in the clinical resolution of these diseases is covered by clinical members of faculty. The latest in genetics, the hereditary aspects of some of these diseases, and the molecular diagnosis of haematological disorders is taught by our scientific community.

This will be a taught module delivered through lectures. Subject matter will include normal haemopoiesis, the achievement of haemostasis and the diseases associated with de-regulated haemostasis. The student will go on to acquire an associated knowledge of haemorrhagic and thrombotic disorders. Key elements of red cell abnormalities including the thalassaemias, sickle cell disease and certain anaemias e.g. Diamond Blackfan, are covered in-depth. The science and clinical aspects of blood transfusion will be covered. The module will encompass inherited bone marrow failures illustrated by lectures on monogenic disorders associated with aplastic anaemia such as Fanconi anaemia and dyskeratosis congenita. Progress in the clinical resolution of these diseases is covered by clinical members of faculty. The latest in genetics, the hereditary aspects of some of these diseases, and the molecular diagnosis of haematological disorders is taught by our scientific community.

  1. To discuss critically the production of blood cells via haematopoiesis.
  2. Analyse the haemostasis and the diseases associated with bleeding disorders.
  3. To discuss an in-depth knowledge of blood transfusion.
  4. Critically discuss in-depth red cell disorders such as thalassaemia, sickle cell disease and the science behind haemoglobinopathies.
  5. Evaluate the latest developments in bone marrow failures.
  6. Critique the biology, and the scientific developments behind clinical advances in haematological therapeutics.

Examination 80%

Coursework 20%

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