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Professor Charles Knowles

Charles

Deputy Director for Research

Email: c.h.knowles@qmul.ac.uk
Telephone:  Ext. 8757

Summary

 

Professor Knowles is Director of the NIHR Enteric Healthcare Technology Cooperative, Director of the National Bowel Research Centre and Surgical Specialty Lead for North Thames NIHR CRN. He holds research positions in the European Society of Coloproctology and Association of Coloproctology of Great Britain and Ireland. He is Chair to UEG-led international working groups in anorectal physiology and GI neuromuscular diseases. He serves as a member of the Rome IV committee for anorectal disorders and is on the global expert panel for Medtronic. He is a panel member for NIHR i4i and is on the editorial board of two journals. He has authored over 150 peer-reviewed publications as well as contributing several book chapters to major colorectal and general surgical texts.

 

 

Research

Publications

Horrocks EJ, Chadi S, Stevens N, Wexner S, Knowles CH. Predictors of efficacy of percutaneous tibial nerve stimulation for fecal incontinence: a post-hoc analysis of a randomized trial" (CGH-D-17-00954). Clinical Gastroenterology and Hepatology 2017 (epub ahead of print).

McGuire C, Boundouki G, Hockley JR, Reed D, Cibert-Goton V, Peiris M, Kung V, Broad J, Aziz Q, Chan C, Ahmed S, Thaha MA, Sanger GJ, Blackshaw LA, Knowles CH, Bulmer DC. Ex vivo study of human visceral nociceptors. Gut. 2016 Sep 21. pii:gutjnl-2016-311629. doi: 10.1136/gutjnl-2016-311629. [Epub ahead of print]

Rao SS, Bharucha AE, Chiarioni G, Felt-Bersma R, Knowles C, Malcolm A, Wald A. Functional Anorectal Disorders. Gastroenterology 2016 Mar 25 [Epub ahead of print].

Grossi U, Carrington EV, Bharucha AE, Horrocks EJ, Scott SM, Knowles CH. Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defaecation. Gut 2016; 65: 447-55.

Hockley JR, Tranter MM, McGuire C, Boundouki G, Cibert-Goton V, Thaha MA, Blackshaw LA, Michael GJ, Baker MD, Knowles CH, Winchester WJ, Bulmer DC. P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. J Neurosci. 2016; 36:2364-76.

Thaha MA, Abukar AA, Thin NN, Ramsanahie A, Knowles CH. Sacral nerve stimulation for faecal incontinence and constipation in adults. Cochrane Database Syst Rev 2015 Aug 24;8:CD004464.

Knowles CH, Horrocks EJ, Bremner SA, Stevens N, Norton C, O'Connell PR, Eldridge S; CONFIDeNT study group. Percutaneous tibial nerve stimulation versus sham electrical stimulation for the treatment of faecal incontinence in adults (CONFIDeNT): a double-blind, multicentre, pragmatic, parallel-group, randomised controlled trial. Lancet 2015; 386(10004):1640-8.

Altomare DF, Giuratrabocchetta S, Knowles CH, Muñoz Duyos A, Robert-Yap J, Matzel KE; the European SNS Outcome Study Group. Long-term outcomes of sacral nerve stimulation for faecal incontinence. Br J Surg. 2015; 102:407-415.

Thin N, Taylor SJC, Bremner SA, Emmanuel AV, Hounsome N, Williams NS, Knowles CH. Randomized clinical trial of sacral and percutaneous tibial nerve stimulation in patients with faecal incontinence. Br J Surg 2015; 102: 349-358.

Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O'Connell PR, Jones JF. Effects of stimulation frequency and intensity in sacral neuromodulation on anorectal inputs to the somatosensory cortex in an experimental model. Br J Surg 2014; 101:1317-28.

Hockley JR, Boundouki G, Cibert-Goton V, McGuire C, Yip PK, Chan C, Tranter M, Wood JN, Nassar MA, Ashley Blackshaw L, Aziz Q, Michael GJ, Baker MD, Winchester WJ, Knowles CH, Bulmer DC. Multiple Roles for Na(V)1.9 in the Activation of Visceral Afferents by Noxious Inflammatory, Mechanical and Human Disease Derived Stimuli. Pain. 2014;155: 1962-75

Botha C, Farmer AD, Nilsson M, Brock C, Gavrila AD, Drewes AM, Knowles CH, Aziz Q. Preliminary report: modulation of parasympathetic nervous system tone influences oesophageal pain hypersensitivity. Gut. 2015; 64:611-7.

Hayat JO, Gabieta-Somnez S, Yazaki E, Kang JY, Woodcock A, Dettmar P, Mabary J, Knowles CH, Sifrim D. Pepsin in saliva for the diagnosis of gastro-oesophageal reflux disease. Gut 2014 64(3):373-80.

Hotouras A, Murphy J, Walsh U, Allison M, Curry A, Williams NS, Knowles C, Chan CL. Outcome of Percutaneous Tibial Nerve Stimulation (PTNS) for Fecal Incontinence: A Prospective Cohort Study. Ann Surg. 2014; 259:939-43.

Athanasakos EP, Kemal KI, Malliwal RS, Scott SM, Williams NS, Aziz Q, Ward HC, Knowles CH. A controlled study of clinical and psychosocial functioning in adolescents and young adults with anorectal malformations and chronic idiopathic constipation. Br J Surg 2013; 100: 832-9.

Knowles CH, Panza E, Lindberg G, De Giorgio R. New perspectives in the diagnosis and management of enteric neuropathies. Nat Rev Gastroenterol Hepatol 2013;10:206-18.

Knowles CH, Thin N, Gill K, Bhan C, Grimmer K, Lunniss PJ, Williams NS, Scott M. Prospective randomized double-blind study of sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Ann Surg 2012; 255: 643-9.

Peiris M, Bulmer D, Baker M, Boundouki G, Sinha S, Hobson A, Lee K, Aziz Q, Knowles CH. Human visceral afferent recordings: preliminary report. Gut 2011; 60: 204-8.

Knowles CH, Thin N, Gill K, Bhan C, Grimmer K, Lunniss PJ, Williams NS, Scott M. Prospective randomized double-blind study of sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. In press: Ann Surg July 2011.

Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T. The London Classification of GI Neuromuscular disease. Gut 2010; 59: 882-887.

Knowles CH, Aziz Q. Basic and clinical aspects of gastrointestinal pain. Pain 2009; 141: 191-209.

Nastro P, Knowles CH, McGrath A, Heyman B, Porrett TR, Lunniss PJ. Complications of intestinal stomas. Br J Surg. 2010; 97: 1185-9.

Knowles CH, De Giorgio R, Kapur RP, Bruder E, Farrugia G, Geboes K, Gershon MD, Hutson J, Lindberg G, Martin JE, Meier-Ruge WA, Milla PJ, Smith VV, Vandervinden JM, Veress B, Wedel T. Gastrointestinal neuromuscular pathology: guidelines for histological techniques and reporting on behalf of the Gastro 2009 International Working Group. Acta Neuropathol 2009; 118: 271-301.

Martin JE, Hester TW, Aslam H, Sinha S, Knowles CH. Discordant practice and limited histopathological assessment in gastrointestinal neuromuscular disease. Gut 2009; 58: 1703-5.

Hubball A, Lang B, De Giorgio R, Martin JE, Knowles CH. The role of humoral autoimmunity in Gastrointestinal neuromuscular disease. Prog Neurobiol 2008; 87: 10-20.

Gooneratne M, Facer P, Knowles CH, Frye J, Chan C, Anand P, Williams NS. Elevated rectal mucosal substance P levels in patients with faecal incontinence are normalised by successful sacral nerve stimulation. Br J Surg 2008; 95: 477-83.

Knowles CH, Veress B, Tornblom H, Wallace S, Paraskevas P, Darzi A, Martin JE, Nyborg B, Lindberg G. Safety and diagnostic yield of laparoscopically assisted full-thickness bowel biospy. Neurogastroenterol Motil 2008; 20: 774-9.

Williams NS, Murphy J, Knowles CH. The Anterior Perineal PlanE for ultra low Anterior Resection (the APPEAR technique): a pilot study. Ann Surg 2008; 247: 750-758.


View all Charles Knowles's Research Publications at: http://www.researchpublications.qmul.ac.uk

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