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Dr Mark Scott

Mark

Senior Clinical Scientist Director, GI Physiology Unit (Colorectal Service)

Summary

Mark Scott, PhD is a Principal Investigator within the Blizard Institute at Queen Mary University of London, and is Director and one of the founders of the internationally-renowned GI (Colorectal) Physiology Unit at Barts and The London School of Medicine and Dentistry / Barts Health NHS Trust. Approximately 1000 patients undergo diagnostic investigations within the Unit each year, which provides the resources for allied research.

Mark has over 25 years’ experience, both clinical and academic, related to the physiological assessment of functional colorectal disorders (primarily constipation and faecal incontinence). Research interests are focussed on pathophysiology and treatment, including:

  1. pioneering work on visceral hyposensitivity
  2. assessment of colonic motor function
  3. development of novel investigative technologies (including ingestible telemetric devices, and high-resolution manometry)
  4. evaluation of novel therapies for both constipation and incontinence.

He is the most widely published colorectal GI Physiologist in the UK, having authored 135 original articles and 10 book chapters. He is Guest Editor of 2 journal supplements devoted to the subject of chronic constipation, and is currently one of the European Society of Neurogastroenterology and Motility Working Team members setting guidelines for the management of constipation. Mark is also one of the Leads of an International Anorectal Physiology Working Group into standardisation of diagnostic testing. He has supervised numerous postgraduate students (both clinical and scientific) to successful completion of their higher degrees.

Research

Publications

Rao SS, Camilleri M, Hasler WL, Maurer AH, Parkman HP, Saad R, Scott MS, Simren M, Soffer E, Szarka L. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil 2011: 23: 8-23.

  1. Scott SM, van den Berg MM, Benninga MA. Rectal sensorimotor dysfunction in constipation. Best Pract Res Clin Gastroenterol 2011: 25; 103-18.
  2. Scott SM, Knowles CH. Dried plums (prunes) for the treatment of constipation. Nat Rev Gastroenterol Hepatol 2011: 8: 306-7.
  3. Dinning PG, Scott SM. Novel diagnostics and therapy of colonic motor disorders. Curr Opin Pharmacol 2011: 11: 624-9.
  4. Knowles CH, Thin N, Gill K, Bhan C, Grimmer K, Lunniss PJ, Williams NS, Scott SM. Prospective randomized double-blind proof of mechanism study of sacral nerve stimulation in patients with rectal evacuatory dysfunction and rectal hyposensitivity. Ann Surg 2012: 255: 643-9.
  5. Palit S, Lunniss PJ, Scott SM. The physiology of human defecation. Dig Dis Sci 2012: 57: 1445-64.
  6. Burgell R, Lelic D, Carrington EV, Lunniss PJ, Olesen SS, Surguy S, Drewes AM, Scott SM. Assessment of rectal afferent neuronal function and brain activity in patients with constipation and rectal hyposensitivity. Neurogastroenterol Motil 2013: 25: 260-e168.
  7. Athanasakos EP, Kemal KI, Malliwal RS, Scott SM, Williams NS, Aziz Q, Ward HC Knowles CH. A controlled study of clinical and psychosocial functioning in adolescents and young adults with anorectal malformations and chronic idiopathic constipation. Br J Surg 2013: 100: 832-9.
  8. Carrington EV, Brokjær A, Craven H, Zarate N, Horrocks EJ, Palit S, Jackson W, Duthie GS, Knowles CH, Lunniss PJ, Scott SM. Traditional measures of normal anal sphincter function using high-resolution anorectal manometry (HRAM) in 115 healthy volunteers. Neurogastroenterol Motil 2014: 26: 625-35.
  9. Palit S, Bhan C, Lunniss PJ, Boyle DJ, Gladman MA, Knowles CH, Scott SM. Evacuation proctography: a reappraisal of normal variability. Colorectal Dis 2014: 16: 538-46.
  10. Dimidi E, Christodoulides S, Fragkos K, Scott SM, Whelan K. ­The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. Am J Clin Nutr 2014: 100: 1075-84.
  11. Wang YT, Mohammed SD, Farmer AD, Wang D, Zarate N, Hobson AR, Hellström PM, Semler JR, Kuo B, Rao SS, Hasler WL, Camilleri M, Scott SM. Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol. Aliment Pharmacol Ther 2015: 42: 761-72.
  12. Dinning PG, Carrington EV, Scott SM. Colonic and anorectal motility testing in the high resolution era. Curr Opin Gastroenterol 2016: 32: 44-8.
  13. Grossi U, Carrington EV, Bharucha AE, Horrocks EJ, Scott SM, Knowles CH. Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic defecation. Gut 2016: 65: 447-55.
  14. Christodoulides S, Dimidi E, Fragkos KC, Farmer AD, Whelan K, Scott SM. Effect of fibre supplementation on chronic idiopathic constipation in adults: systematic review and meta-analysis of randomised controlled trials. Aliment Pharmacol Ther 2016: 44: 103-16.
  15. Palit S, Thin N, Knowles CH, Lunniss PJ, Bharucha AE, Scott SM. Diagnostic disagreement between tests of evacuatory function: a prospective study of 100 constipated patients. Neurogastroenterol Motil 2016: 28: 1589-98.
  16. Farmer AD, Pedersen AG, Brock B, Jakobsen PE, Karmisholt J, Mohammed SD, Scott SM, Drewes AM, Brock C. Type 1 diabetic patients with peripheral neuropathy have pan-enteric prolongation of gastrointestinal transit times and an altered cecal pH profile. Diabetologia 2017: 60: 709-18.
  17. Dimidi E, Christodoulides S, Scott SM, Whelan K. Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation. Adv Nutr 2017: 8: 484-94.
  18. Keller J, Bassotti G, Clarke J, Dinning P, Fox M, Grover M, Hellström PM, Ke M, Layer P, Malagelada C, Parkman HP, Scott SM, Tack J, Simren M, Törnblom H, Camilleri M. Consensus statement on diagnosis and classification of gastric and intestinal motility disorders. Nat Rev Gastroenterol Hepatol 2017: in press
  19. Fox M, Kahrilas PJ, Roman S, Gyawali CP, Scott SM, Rao S, Keller J, Camilleri M. Clinical measurement of gastrointestinal motility and function: who and when to refer, and for which test? Nat Rev Gastroenterol Hepatol 2017: in press

 

 

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