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Professor Adina Michael-Titus, Lic Sci., M es Sci.,  Doct en Sci.

Adina

Professor of Neuroscience

Email: A.T.Michael-Titus@qmul.ac.uk
Telephone: 020 7882 2290

Profile

Adina Michael-Titus was awarded a Doctorat en Sciences (France) in 1988, for studies on novel inhibitors of opioid peptide-degrading enzymes. She continued post-doctoral studies on opioid peptides, in Rouen and Paris until 1990, when she was offered the position of Lecturer in Physiology and Pharmacology in the School of Biological Sciences at Queen Mary. She became subsequently a Lecturer in Pharmacology at Barts and The London School of Medicine, and a Senior Lecturer in 2001. Between 2002 and 2004 she spent sabbatical research time as a Senior Scientist and Head of Section in Drug Discovery, with the pharmaceutical company Lundbeck A/S in Denmark. She became a Reader in 2007 and was awarded the title of Professor of Neuroscience in 2010.

Summary

Professor Adina Michael-Titus is the Lead of the Neurotrauma and Neurodegeneration Group in the Centre for Neuroscience and Trauma. She teaches neuroscience, pharmacology and therapeutics, and has a particular research interest in the characterization and development of novel therapeutic approaches in several neurological diseases. She is Programme Director of the MSc in Neuroscience and Translational Medicine, whose main aim is to help train the next generation of scientists and physicians involved in rapid and successful clinical translation of fundamental discoveries in neuroscience. 

A large component of her present research programme is focused on neuroprotective agents in acute spinal cord injury and spinal cord neurodegeneration. Several of her present projects explore the remarkable therapeutic potential of natural compounds, such as the n-3 polyunsaturated fatty acids.  Her group has also started a programme of studies on new therapeutic directions in Alzheimer’s disease. She is an inventor on several patents, a member of several scientific and professional societies and regularly acts as a reviewer for the UK research councils. 

Teaching

  • MBBS: Brain and Behaviour course (module convenor Year 2); SSC modules Year 2 and Year 4
  • Intercalated BSc Neuroscience (modules: Cell and Molecular Neuroscience; Disconnected Pathways; Brain and Mind – module convenor)
  • Intercalated BMed Sci
  • MSc Neuroscience and Translational Medicine (Programme Director)

Topics for PhD supervision:

  • New neuroprotective strategies in in spinal cord injury and head injury
  • Characterization of new metal binding compounds with therapeutic potential in neurodegenerative disease
  • Biomarkers of acute neuronal  injury and neurodegeneration

Research

Research Interests:

Neuroprotection; Neuroregeneration; Spinal cord injury; Head injury; Alzheimer’s disease; Schizophrenia

Recent and ongoing research projects

  • Development of  fatty acid emulsions for use in acute neuroprotection in spinal cord injury
  • Investigation of orally available neuroprotective preparations for use in chronic spinal cord injury
  • New metal-binding compounds with neuroprotective properties in Alzheimer’s disease

Publications

Penschuck, S , Flagstad, P , Didriksen, M , Leist, M , Michael-Titus AT .: Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. Eur. J. Neurosci., 23, 279-284. (2006). 

King, V.R., Huang, W.L., Dyall, S.C. , Curran, O.E., Priestley. J.V., Michael-Titus, A.T.: Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J. Neurosci., 26, 4672-4680 (2006). 

Dyall, S.C ., Michael, G.J ., Whelpton, R ., Scott, A.G ., Michael-Titus, AT Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol. Aging, 28,424-439 (2007). 

Huang, W.L., King, V.R., Curran, O.E., Dyall, S.C. , Ward, R.E., Lal, N., Priestley, J.V., Michael-Titus A.T. : A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury, Brain 130, 3004-3019 (2007). 

Huang, W., Bhavsar, A., Ward, R.E., Hall, J.C., Priestley, J.V., Michael-Titus, A.T. Arachidonyl trifluoromethylketone is neuroprotective after spinal cord injury. J. Neurotrauma, 26, 1429-34 (2009). 

Michael-Titus, A.T: Omega-3 fatty acids: their neuroprotective and regenerative potential in traumatic neurological injury. Clin. Lipidology, 4 (3), 343-35 (2009). 

Dyall, S.C., Michael, G.J., Michael-Titus, A.T. Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J. Neurosci. Res, 88, 2091-20102 (2010). 

Ward, R.E., Huang, W., Curran, O.E., Priestley, J.V.,  Michael-Titus, A.T.: Docosahexaenoic acid prevents white matter damage following spinal cord injury. J Neurotrauma, 27, 1769-1780 (2010).


View all Adina Michael-Titus's Research Publications at: http://www.researchpublications.qmul.ac.uk

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