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Professor Paolo Pozzilli, MB BS, MD

Paolo

Professor of Diabetes and Clinical Research

Email: p.p.pozzilli@qmul.ac.uk
Telephone: 020 7882 2392

Profile

Profile Paolo Pozzilli is Professor of Diabetes and Clinical Research at the Centre for Diabetes at Barts and The London School of Medicine & Dentistry, London, and Professor of Endocrinology & Metabolic Diseases at the University Campus Bio-Medico in Rome, Italy.

He qualified in Medicine at "Sapienza" University in Rome and specialized in Endocrinology and Metabolic Diseases at the same University. He has participated in 4 Biomed projects of the European Union and 3 NIH projects. He is Member of Ancillary Study Committee for the TRIGR Study (NIH project), Chairman of the IMDIAB Group and Deputy Chairman of the ACTION LADA Project (EU).

He coordinates the International PhD programme in Endocrinology and Metabolic Diseases between Queen Mary University of London, University Campus Bio-Medico in Rome and the University of Ulm, Germany.

He is Member Scientific Advisory Board of the Graduate School in Molecular Medicine, University of Ulm, Member Advisory Board of the International Diabetes Federation, Group for Diabetes in the Youth and Delegate for University Campus Bio-Medico, Permanent Conference of Rectors of the Italian Universities (CRUI).

He is currently the European Editor of Diabetes Metabolism Research & Reviews, John Wiley Publ.

He was the recipient of several awards including the Andrew Cudworth Memorial Prize of the British Diabetic Association (1986), the G.B. Morgagni Prize, Young Investigator Award of the European Association of Metabolism (1989), the SID Prize 1994 (Italian Society of Diabetes), the Karol Marcinkowski Medal of the "Poznan Academy of Medicine" Poland (1997), the Mary Jane Kugel Award, Juvenile Diabetes Research Foundation, USA (2003 and 2006) and the Diabetes Honoris Causa, Paulescu Foundation & Romanian Society of Diabetes (2007).

Professional Organizations:
Member Advisory Board NAIMIT Project (EU)
Member of the Executive Committee of the International Centre
for the Study of  Diabetes (CISD) (Rome)
Member Scientific Advisory Board, Graduate School in Molecular Medicine, University of  Ulm
Member Advisory Board, International Diabetes Federation, Group for Diabetes in the Youth
Member Ethical Committee, University Campus Bio-Medico di Roma
Delegate for University Campus Bio-Medico, Permanent Conference of Rectors of the Italian Universities (CRUI)
Member Research Board, University Campus Bio-Medico di Roma

Editorial Boards;
European Editor, Diabetes/Metabolism Research and Reviews
Member Editorial Board “The Endocrinologist”.

Summary

Research projects focus on the pathogenesis of type 1 diabetes (T1DM) taking advantage of a large database of DNA and sera from patients with T1DM and related auto immuno diseases.

Early diagnosis and prevention of beta-cell destruction in patients affected by T1DM and LADA (Latent autoimmune diabetes in adults) are among study priorities. Research focuses on the epidemiological, genetic and immunological aspects of diabetes associating with other diseases such as rheumatoid arthritis.

In collaboration with academic Institutions in Europe special attention is paid to intervention trials for protection of residual beta cell function in T1DM. More recently studies are ongoing on the use of immunomodulatory drugs at diagnosis at T1DM, thus offering novel approaches for treatment of this condition.

Studies are ongoing to generate insulin producing cells from adult mesenchymal stem cells. The project includes several steps from the establishment of the best conditions for the isolation and culture of mesenchymal stem cells obtained from abdominal fat to their proliferation and differentiation into different cell types such insulin producing cells as well as osteoblasts and condroblasts. These cells have been selected because they are easily obtainable in humans and may be applied safely in translational medicine.

A special link has been established with University Campus Bio-Medico in Rome, Italy, covering the Erasmus exchange programme for undergraduate medical students, a postgraduate PhD programme in Endocrinology and Metabolic Diseases and teacher exchange in Diabetes and Metabolic Diseases.

Teaching

MSc, international PhD Programme in Endocrinology and Diabetes.
Modules taught: diabetes

Topics for PhD supervision:

Diabetes, autoimmunity, genetics, beta cell regeneration, immunotherapy of Diabetes.


Research

Research Interests:

Autoimmune and genetic aspects of diabetes, immunotherapy of type 1 diabetes, regeneration of beta cells.

Publications

Tuccinardi D, Fioriti E, Manfrini S, D'Amico E, Pozzilli P.
DiaPep277 peptide therapy in the context of other immune intervention trials in type 1 diabetes.
Expert Opin Biol Ther. 2011 Jul 13. [Epub ahead of print]

Barchetta I, Angelico F, Del Ben M, Baroni MG, Pozzilli P, Morini S, Cavallo MG.
Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes.
BMC Med. 2011 Jul 12;9(1):85. [Epub ahead of print]

Di Stasio E, Maggi D, Berardesca E, Marulli GC, Bizzarri C, Lauria A, Portuesi R, Cavallo MG, Costantino F, Buzzetti R, Astorri E, Pitocco D, Songini M, Pozzilli P; and the IMDIAB group.
Blue eyes and fair skin as risk factors for type 1 diabetes.
Diabetes Metab Res Rev. 2011 May 6.

Pozzilli P, Guglielmi C, Caprio S, Buzzetti R.
Obesity, autoimmunity, and double diabetes in youth.
Diabetes Care. 2011 May;34 Suppl 2:S166-70.

Vadacca M, Valorani MG, von Hofe E, Kallinteris NL, Buzzetti R, Pozzilli P.
Recognition of Ii-Key/MHC Class II Epitope Hybrids Derived from Proinsulin and GAD Peptides by T Cells in Type 1 Diabetes.
Horm Metab Res. 2011 Jun;43(7):483-8.

Napoli N, Pedone C, Pozzilli P, Lauretani F, Bandinelli S, Ferrucci L, Incalzi RA.
Effect of ghrelin on bone mass density: The InChianti study.
Bone. 2011 Aug;49(2):257-63.

Haller H, Ito S, Izzo JL Jr, Januszewicz A, Katayama S, Menne J, Mimran A, Rabelink TJ, Ritz E, Ruilope LM, Rump LC, Viberti G; ROADMAP Trial Investigators.
Olmesartan for the delay or prevention of microalbuminuria in type 2 diabetes.
N Engl J Med. 2011 Mar 10;364(10):907-17.

Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum W, Seissler J, Kolb H, Hunter S, Leslie RD, Schloot NC; Action LADA Study Group.
Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4.
Diabetologia. 2011 Jul;54(7):1630-8.

Bizzarri C, Patera PI, Arnaldi C, Petrucci S, Bitti ML, Scrocca R, Manfrini S, Portuesi R, Buzzetti R, Cappa M, Pozzilli P; Immunotherapy Diabetes (IMDIAB) Group.
Incidence of type 1 diabetes has doubled in Rome and the Lazio region in the 0- to 14-year age-group: a 6-year prospective study (2004-2009).
Diabetes Care. 2010 Nov;33(11):e140.

Astorri E, Guglielmi C, Bombardieri M, Alessandri C, Buzzetti R, Maggi D, Valesini G, Pitzalis C, Pozzilli P.
Circulating Reg1α proteins and autoantibodies to Reg1α proteins as biomarkers of β-cell regeneration and damage in type 1 diabetes.
Horm Metab Res. 2010 Dec;42(13):955-60.

Bizzarri C, Pitocco D, Napoli N, Di Stasio E, Maggi D, Manfrini S, Suraci C, Cavallo MG, Cappa M, Ghirlanda G, Pozzilli P; IMDIAB Group.
No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial.
Diabetes Care. 2010 Sep;33(9):1962-3.

Astorri E, Bombardieri M, Gabba S, Peakman M, Pozzilli P, Pitzalis C.
Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic islets.
J Immunol. 2010 Sep 15;185(6):3359-68.

Hilner JE, Perdue LH, Sides EG, Pierce JJ, Wägner AM, Aldrich A, Loth A, Albret L, Wagenknecht LE, Nierras C, Akolkar B; T1DGC.
Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC).
Clin Trials. 2010;7(1 Suppl):S5-S32.

Bruno G, Maule M, Merletti F, Novelli G, Falorni A, Iannilli A, Iughetti L, Altobelli E, d'Annunzio G, Piffer S, Pozzilli P, Iafusco D, Songini M, Roncarolo F, Toni S, Carle F, Cherubini V; RIDI Study Group.
Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study.
Diabetes. 2010 Sep;59(9):2281-7.

Zampetti S, Spoletini M, Petrone A, Capizzi M, Arpi ML, Tiberti C, Di Pietro S, Bosi E, Pozzilli P, Giorgino F, Buzzetti R; Nirad Study Group.
Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5).
Diabet Med. 2010 Jun;27(6):701-4.

Pozzilli P, Leslie RD, Chan J, De Fronzo R, Monnier L, Raz I, Del Prato S.
The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach.
Diabetes Metab Res Rev. 2010 May;26(4):239-44.

Valorani MG, Germani A, Otto WR, Harper L, Biddle A, Khoo CP, Lin WR, Hawa MI, Tropel P, Patrizi MP, Pozzilli P, Alison MR.
Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential.
Cell Tissue Res. 2010 Jul;341(1):111-20.

Napoli N, Mottini G, Arigliani M, Creta A, Giua R, Incammisa A, Carotti S, Sihom F, Yimagou I, Alombah R, Mbanya JC, Pozzilli P.
Unexpectedly high rates of obesity and dysglycemia among villagers in Cameroon.
Diabetes Metab Res Rev. 2010 Jan;26(1):10-2.

Cardwell CR, Stene LC, Joner G, Davis EA, Cinek O, Rosenbauer J, Ludvigsson J, Castell C, Svensson J, Goldacre MJ, Waldhoer T, Polanska J, Gimeno SG, Chuang LM, Parslow RC, Wadsworth EJ, Chetwynd A, Pozzilli P, Brigis G, Urbonaite B, Sipetić S, Schober E, Ionescu-Tirgoviste C, de Beaufort CE, Stoyanov D, Buschard K, Patterson CC.
Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data.
Diabetologia. 2010 Apr;53(4):641-51.

Cardwell CR, Stene LC, Joner G, Bulsara MK, Cinek O, Rosenbauer J, Ludvigsson J, Jané M, Svensson J, Goldacre MJ, Waldhoer T, Jarosz-Chobot P, Gimeno SG, Chuang LM, Parslow RC, Wadsworth EJ, Chetwynd A, Pozzilli P, Brigis G, Urbonaite B, Sipetic S, Schober E, Devoti G, Ionescu-Tirgoviste C, de Beaufort CE, Stoyanov D, Buschard K, Patterson CC.
Maternal age at birth and childhood type 1 diabetes: a pooled analysis of 30 observational studies.
Diabetes. 2010 Feb;59(2):486-94.

Cernea S, Raz I, Herold KC, Hirshberg B, Roep BO, Schatz DA, Fleming GA, Pozzilli P, Little R, Schloot NC, Leslie RD, Skyler JS, Palmer JP; D-Cure Workshop.
Challenges in developing endpoints for type 1 diabetes intervention studies.
Diabetes Metab Res Rev. 2009 Nov;25(8):694-704.

Home PD, Pocock SJ, Beck-Nielsen H, Curtis PS, Gomis R, Hanefeld M, Jones NP, Komajda M, McMurray JJ; RECORD Study Team.
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial.
Lancet. 2009 Jun 20;373(9681):2125-35.

Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS; Type 1 Diabetes Genetics Consortium.
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Nat Genet. 2009 Jun;41(6):703-7.

Pozzilli P, Leslie RD.
New prospects for immunotherapy at diagnosis of type 1 diabetes.
Diabetes Metab Res Rev. 2009 May;25(4):299-301.

Khoo CP, Valorani MG, Brittan M, Alison MR, Warnes G, Johansson U, Hawa M, Pozzilli P.
Characterization of endothelial progenitor cells in the NOD mouse as a source for cell therapies.
Diabetes Metab Res Rev. 2009 Jan;25(1):89-93.

Beyan H, Buckley LR, Bustin SA, Yousaf N, Pozzilli P, Leslie RD.
Altered monocyte cyclo-oxygenase response in non-obese diabetic mice.
Clin Exp Immunol. 2009 Feb;155(2):304-10.

Hawa MI, Thivolet C, Mauricio D, Alemanno I, Cipponeri E, Collier D, Hunter S, Buzzetti R, de Leiva A, Pozzilli P, Leslie RD; Action LADA Group.
Metabolic syndrome and autoimmune diabetes: action LADA 3.
Diabetes Care. 2009 Jan;32(1):160-4.


View all Paolo Pozzilli's Research Publications at: http://www.researchpublications.qmul.ac.uk

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