Professor Lucinda Hall
Professor of Molecular Microbiology
Email: email@example.comTelephone: 020 7882 2323
Lucinda Hall graduated in Biology from the University of York in 1978, and gained her PhD from the University of Glasgow in 1981. She joined what was then the London Hospital Medical College in 1986 following four and a half years of post-doctoral research in molecular biology at the University of Geneva. She became Professor of Molecular Microbiology in 2010 and was elected Centre Lead in 2009-2013.
If we use antibiotics to treat infection we cannot avoid encouraging the growth of bacteria that are able to resist the effects of the antibiotics. Some bacteria, often called “superbugs”, have been particularly successful in hospitals and other places where a lot of antibiotics are used. Apart from good hygiene, can we do something more clever to prevent antibiotic resistance from taking over in bacterial populations?
Lucinda Hall’s research interests centre on the evolution of bacterial pathogens, particularly in relation to antibiotic resistance. Early development of molecular typing methods and the determination of antibiotic resistance mechanisms led to an interest in bacterial population structures and the factors that drive the acquisition, spread, and maintenance of resistance. Following the demonstration that resistance to sulphonamides in Escherichia coli is maintained despite minimal recent use in medicine, one interest is in the factors that underlie this persistence of resistance. Other projects relate to the genetic mechanisms of mutation in Streptococcus pneumoniae, particularly in relation to the evolution of multiresistant strains with international spread. A developing area of research is in the microbiota of the gut and its interaction with the host in health and disease, in collaboration with groups within and outside the Centre. Manipulation of bacterial populations on the skin or in the gut is one potential route to limiting the spread of antibiotic resistance.
With a background in molecular genetics, Lucinda teaches on the biology of bacteria and the role of molecular techniques in clinical microbiology.
Deputy Dean for Education (Science Undergraduate Studies) in the School of Medicine and Dentistry
Topics for PhD supervision:
Antibiotic resistance, Streptococcus pneumoniae, human microbiota
Bacterial evolution, antibiotic resistance, bacterial population genetics, Streptococcus pneumoniae, bacteria of the gut
Recent and ongoing research projects:
- Impact of resistance plasmids on bacterial fitness (with Vicky Enne).
- DNA repair and the role of DinB DNA polymerase In Streptococcus pneumoniae.
- Effect of enteral feeding on gut microbiota in Crohn’s disease (with Prof Ian Sanderson)
Henderson-Begg, SK, Sheppard, CL, George, RC, Livermore, DM, Hall, LMC (2010) Mutation frequency in antibiotic-resistant and susceptible isolates of Streptococcus pneumoniae. Int J Antimicrob Agents 35, 342-6
Sheppard, CL, Pichon, B George, RC, Hall, LMC (2010) Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B. Clin Vaccine Immunol 17, 1820-2.
Henderson-Begg, SK, Roberts, A, Hall, LMC (2009) Diversity of putative Tn5253-like elements in Streptococcus pneumoniae. Int J Antimicrob Agents 33, 364-7.
Bean, DC, Livermore, DM, Hall, LMC (2009) Characterization of plasmids imparting sulphonamide resistance in Escherichia coli: implications for persistence. Antimicrob Agents and Chemother 53, 1088-93.
View all Lucinda Hall's Research Publications at: http://www.researchpublications.qmul.ac.uk