Dr Louisa James, BSc (Hons), PhD
Lecturer in Immunology
Email: firstname.lastname@example.org Telephone: 020 7882 2329
Research in Dr James’ group is focussed on understanding how B cell memory is regulated and maintained. Of particular interest is how different microenvironments influence B cell development and antibody production. We use a combination of cellular, molecular, biophysical and computational approaches to analyse B cells and antibody repertoires in human blood and tissue samples.
Our goal is that by understanding how B cell memory is induced and maintained we can develop strategies that manipulate antibody responses for therapeutic benefit. A particular area of interest is allergy, where we have demonstrated that manipulation of antibody responses through allergen immunotherapy, has the potential to redress the balance between tolerance and disease.
Dr James obtained a BSc in Immunology from King’s College London in 2002. She completed a PhD on the immune mechanisms of allergen immunotherapy, under the supervision of Professor Stephen Durham (National Heart & Lung Institute, Imperial College London). She then returned to King’s College London for post-doctoral training under the supervision of Professor Mark Peakman (Division of Immunology, Infection & Inflammatory Disease) working on a study of peptide immunotherapy for Type 1 Diabetes. In 2009 Dr James joined the laboratory of Professor Hannah Gould and Professor Brian Sutton (Randall Division of Cell & Molecular Biophysics) to study antibody responses in allergy. Dr James joined the Centre of Immunobiology in the Blizard institute in 2016 as a Group Leader and Lecturer in Immunology.
Lecturer: BMD351 Advanced Immunology
MBBS - Problem Based Learning
Summary: The regulation of B cell memory is crucial for maintaining health and preventing disease. B cells and the antibodies they produce can determine the balance between tolerance and disease; aberrant antibody production is central to the pathogenesis of many human diseases such as allergy and autoimmunity. Research in our lab aims to determine what regulates the activation and development of B cells.
Current research projects:
- Extrafollicular B cell development and the role of tissue microenvironments in regulating antibody production
- Defining the relationship between B cell phenotype and antibody function
- Characterisation of B cells in the nasal mucosa
- IgG4 as a marker of immune tolerance in allergy
Keywords: Immunology; B cell memory; Antibodies; Allergy; Tissue-specific immunity