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Professor Graham Foster

Professor of Hepatology

Email: g.r.foster@qmul.ac.uk
Telephone: 020 7882 7242

Profile

Professor Foster heads the internationally recognised liver unit at QMUL/Barts Health. He is the national clinical lead for the NHS England Hepatitis C programme and the Chairman of the NHSE Hepatobiliary Clinical Reference Group.

Professor of Hepatology QMUL 2003 – present

Reader in Hepatology Imperial College – 1995- 2002

Lecturer in Molecular Medicine Imperial College 1992-1995

PhD University of London 1988-1992

Summary

Professor Foster is the Professor of Hepatology at  Queen Mary University of London and a consultant at Barts Health Trust. He trained in Medicine at Oxford and London Universities in the 1980s and completed a PhD in Molecular Biology in 1992.  Professor Foster has a long standing interest in the management of chronic viral hepatitis and runs a clinical research program studying the natural history of viral hepatitis, its impact upon patients and their communities and novel therapies for this disease. He supervises a laboratory research program investigating the basic virology of hepatotropic viruses novel replication models for hepatitis C.  He is the sub-editor of The Journal of Viral Hepatitis and has published widely in the field of viral liver disease. He is President of BASL, Vice Chairman the UK Department of Health Advisory Group on Hepatitis and a member of a number of patient advocacy groups.

Research

Research Interests:

Professor Foster leads a laboratory based research group studying drug resistant variants of the hepatitis C virus and their impact on the innate immune system. His group developed a novel replication model for hepatitis C and used the model to identify novel variants in Genotype 3 HCV that inhibit the response to the widely used antiviral nucleotide, sofosbuvir. Rather surprisingly these viral variants interact with interferon signalling and inhibit the anti-viral effects of interferon. Work in the laboratory is concentrated on identifying the mechanisms of this effect.

In addition to his basic scientific research Professor Foster manages an active clinial research programme that over the last five years has focussed on finding and treating patients with chronic viral hepatitis. This work led to his appointment as the NHS England clinical lead in hepatitis C and he works with colleagues on the national drive to eliminate chronic HCV infection in England.

The reducing importance of hepatits C with the advent of effective antiviral therapies has led the group to develop new areas of research and exploratory studies evaluating chronic HBV infection in Africa and its links to hepatocellular carcinoma along with studies on the benefits of physical activity in those who consume alcohol to excess are under way.

Publications

http://www.researchpublications.qmul.ac.uk/publications/

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